Comparison of the effect of adding dexmedetomidine to morphine on duration of mechanical ventilation and heart rate and hypertension in open heart surgery

Comparison effect of Morphine and dexmedtomidine infusion on intubation time and hemodynamic parameters in patients undergone coronary artery bypass surgery who admitted in Intensive Care Unit

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130311012782N39

Enrollment

Registered

2020-02-22

Start date

2020-04-02

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass Graft Surgery. Atherosclerosis of coronary artery bypass graft(s) without angina pectoris

Interventions

Intervention 1: Intervention group: Dexmedetomidine recipient 0.25 µg / kg / hour, plus morphine 0.25 mg / kg/ hour in 50 ml volume upon admission to intensive care unit. Intervention 2: Control group

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient undergoing coronary bypass surgery Heart ejection friction below 40% Patient's consent to participate in the study

Exclusion criteria

Exclusion criteria: Addiction Use of psychotropic and antidepressant drugs Use of Effective drugs on hemodynamic status Use of anticoagulant drugs

Design outcomes

Primary

Measure	Time frame
Duration of mechanical ventilation. Timepoint: In the end of surgery. Method of measurement: Mechanical ventilation machine.;Blood Pressure. Timepoint: Every 15 minutes during operation and recovery. Method of measurement: Pulse Oximeter.;Heart Rate. Timepoint: Every 15 minutes during operation and recovery. Method of measurement: Pulse Oximeter.;Percent of Blood Oxygen Saturation. Timepoint: Every 15 minutes during operation and recovery. Method of measurement: Pulse Oximeter.	—

Measure

Time frame

Duration of mechanical ventilation. Timepoint: In the end of surgery. Method of measurement: Mechanical ventilation machine.;Blood Pressure. Timepoint: Every 15 minutes during operation and recovery. Method of measurement: Pulse Oximeter.;Heart Rate. Timepoint: Every 15 minutes during operation and recovery. Method of measurement: Pulse Oximeter.;Percent of Blood Oxygen Saturation. Timepoint: Every 15 minutes during operation and recovery. Method of measurement: Pulse Oximeter.

—

Secondary

Measure	Time frame
Postoperative complications. Timepoint: Duration of recovery. Method of measurement: Physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirreza Hemasian

Esfahan University of Medical Sciences

amirreza.hemasian@gmail.com+98 31 3668 5555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026