Reduction of nausea ,vomiting and pain of bariatric surgery

Evaluation of the effect of intravenous diphenhydramine injection before anesthesia induction on postoperative pain , nausea and vomiting reduction in bariatric laparoscopic surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130304012695N6

Enrollment

Registered

2020-07-10

Start date

2019-04-14

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Abdominal Acute Pain after laparoscopic bariatric surgery. Condition 2: Postoperative nausea and vomiting. Acute abdomen Vomiting following gastrointestinal surgery

Interventions

Intervention 1: Intervention group: 0.5 mg/kg of diphenhydramine is injected intravenously before anesthesia and the degree of agitation, pain, and hemodynamic changes during extubation, and the incid

Eligibility

Sex/Gender

All

Age

20 Years to 55 Years

Inclusion criteria

Inclusion criteria: Patients with Body mass index grater than 40

Exclusion criteria

Exclusion criteria: History of large prostate disease Glucome Drug addiction uncontrolled hyperthension

Design outcomes

Primary

Measure	Time frame
Incidence and severity of abdominal pain. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Visual Analogue Scale.;Severity of postoperative agitation. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Ramsy sedation Scale.;Incidence of nausea and vomiting. Timepoint: In recovery room and ward. Method of measurement: The number of nausea and vomiting.	—

Measure

Time frame

Incidence and severity of abdominal pain. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Visual Analogue Scale.;Severity of postoperative agitation. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Ramsy sedation Scale.;Incidence of nausea and vomiting. Timepoint: In recovery room and ward. Method of measurement: The number of nausea and vomiting.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Khajavi

Tehran University of Medical Sciences

khajavim@tums.ac.ir+98 21 6312 1220

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026