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The effect of bicarbonate in increasing blood pressure in patients with hemorrhagic shock

Evaluation of hemodynamic effects of bicarbonate infusion in hemorrhagic shock

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130304012695N5
Enrollment
40
Registered
2020-07-04
Start date
2019-06-22
Completion date
Unknown
Last updated
2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: hemorrhagic shock. Condition 2: Acidosis. Hypovolemic shock Acidosis

Interventions

Intervention 1: Intervention group: Patients who has blood loss more than 500 cc during surgery within 20 minutes and have a systolic blood pressure less than 100 mm Hg, sodium bicarbonate infusion

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: All patients whose bleeding is more than 500 cc systolic blood pressure lower than 100 mm patients with ASA I,II,III who are candidates for orthopedic Hip surgery, neurosurgery, and vascular surgery. patients required to receive blood transfusions, patients with hemorrhagic shock

Exclusion criteria

Exclusion criteria: All patients with liver dysfunction lung disorders such as COPD increased ICP Patients who do not agree to participate in this study

Design outcomes

Primary

MeasureTime frame
Lactic Acidosis. Timepoint: At the end of surgery. Method of measurement: Vein blood sample mg/dl.;Blood pressure changes. Timepoint: After the start of bicarbonate or serum at minutes 3-6-9 12-15. Method of measurement: Through the artier line with Lidco device /mmgh.

Secondary

MeasureTime frame
Blood acidosis. Timepoint: At the end of transfusion. Method of measurement: Arterial blood sample.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Khajavi

Tehran University of Medical Sciences

khajavim@tums.ac.ir+98 21 6312 1220

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026