Skip to content

Comparison of sedation of dexmedetomidine-diphenhydramine combination with propofol in outpatient endoscopy and colonoscopy procedures

Comparative study of the sedative effects of Diphenhydramine-Dexmedetomidine combination versus Propofol in outpatient Endoscopy andColonoscopy

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130304012695N22
Enrollment
160
Registered
2025-11-09
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation for Endoscopy and Colonoscopy. Anaesthetics and therapeutic gases

Interventions

Intervention 1: Intervention group: All patients who are candidates for Endoscopy and Colonoscopy who meet the inclusion criteria in the study and are gastrointestinally prepared are admitted to the e

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients aged 20-65 years are candidates for endoscopy and colonoscopy.

Exclusion criteria

Exclusion criteria: History of drug addiction Psychological disorders History of kidney failure Increased liver enzymes Hemodynamic instability Increased body mass index greater than 35

Design outcomes

Primary

MeasureTime frame
Degree of sedation during Endoscopy or Colonoscopy. Timepoint: At the beginning and at minutes 2, 5, 10, and 15 of the procedure. Method of measurement: Modified Observer's Alertness/Sedation scale (MOAA/S).

Secondary

MeasureTime frame
The patient's blood pressure. Timepoint: At the begining and at minutes 2, 5 and 10. Method of measurement: Pneumatic blood pressure monitor.;Heart Rate. Timepoint: At the begining and at minutes 2, 5 and 10. Method of measurement: ECG monitoring.;The patient's arterial oxygen saturation percentage. Timepoint: At the begining and at minutes 2, 5 and 10. Method of measurement: Pulse oximetry.;Recovery time. Timepoint: From the completion of the procedure until the patient's alendronate level reaches more than 8, the patient is recorded as fully conscious and can be discharged. Method of measurement: Alendronate scoring.;Total amount of propofol consumed. Timepoint: At the end of the procedure. Method of measurement: milligrams per minute.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Khajavi

Tehran University of Medical Sciences

KHAGAVIM@TUMS.AC.IR+98 21 6312 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026