Osteoarthritis of knee. Osteoarthritis, unspecified site
Conditions
Interventions
Intervention 1: Intervention group: Methylprednisolone group: methylprednisolone acetate, dose 80 mg, 2 mL, is injected with a 22 G needle in the flat knee and supine position and with the Midpatella
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: Diagnosis of knee osteoarthritis based on ACR (American College of Rheumatology) criteria Failure to respond to drug and non-drug treatments during the last three months Articular cartilage destruction with grade 2 and 3 according to Lawrence-Kellgren criteria in radiological examination BMI less than 35 Patients aged 45-75 years
Exclusion criteria
Exclusion criteria: History of any joint injection or surgery on the knee Skin psoriasis at the injection site or septic arthritis Suffering from systemic diseases such as rheumatoid arthritis and diabetes, history of allergies and sensitivity to the drugs used The patient's unwillingness to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reducing knee pain and swelling. Timepoint: In the period of 2, 4, 8, 12 and 16 weeks after injection. Method of measurement: Numerical rating scale.;Increase the range of movement. Timepoint: In the period of 2, 4, 8, 12 and 16 weeks after injection. Method of measurement: Measuring the amount of increase in the leg movement angle around the knee joint.;Reducing the amount of systemic and analgesic drugs. Timepoint: In the period of 2, 4, 8, 12 and 16 weeks after injection. Method of measurement: Comparison of drug intake with before injection. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarsad Imani
Tehran University of Medical Sciences
Outcome results
None listed