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Analgesic effect of combining Midazolam, Morphine and Diphenhydramine for acute postoperative pain management, A comparative study

Analgesic effect of combining Midazolam, Morphine and Diphenhydramine for acute postoperative pain management, A comparative study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130304012695N2
Enrollment
66
Registered
2020-05-26
Start date
2019-01-21
Completion date
Unknown
Last updated
2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain. Injury of long flexor muscle, fascia and tendon of thumb at wrist and hand level

Interventions

Intervention 1: Intervention group: Morphine, Midazolam, In this group, in a syringe of 10 cc, 10 mg of morphine, 100 mg of diphenhydramine and 10 mg of midazolam,prepared then increase the volume to

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients are extubated after surgery and recover. In recovery, patients were evaluated based on VAS or Richmond criteria, and if they had a VAS> 4 score or Richmond +2 and above, they entered the study and were randomly assigned to one of the two groups.

Exclusion criteria

Exclusion criteria: opioids addiction, underlying ischemic cardiac diseases, renal function and liver function diseases, history of allergic reaction to any of the medications used, and use of any antiemetic and antipsychotic medications, PONV and glaucoma.

Design outcomes

Primary

MeasureTime frame
The effect of the drug combination of midazolam, diphenhydramine and morphine on pain relief. Timepoint: In 5, 10, 15, 30 minutes after the operation, the severity pain was measured. Method of measurement: visual analog scal.

Secondary

MeasureTime frame
Patients' agitation evaluation. Timepoint: In 5, 10, 15 and 30 minutes after surgery. Method of measurement: richmond agitation scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Khajavi

Tehran University of Medical Sciences

khajavim@tums.ac.ir+98 21 6312 1220

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026