Efficacy of prophylactic adminstration of diphenhydramine and dexmedetomidine during anesthesia on emergence agitation and quality of recovery after Orthognathic surgeries.

Evaluation effects of intraoperative injection of diphenhydramine and dexmedetomidine infusion at the end of the operation - on the control of agitation in patients after general anesthesia in orthognathic surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130304012695N19

Enrollment

Registered

2024-05-03

Start date

2024-05-30

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation and analgesia effects of diphenhydramine and dexmedetomidine in orthognathic surgery.

Interventions

Intervention 1: Intervention group: Diphenhydramine drug was injected intravenously before the start of anesthesia and dexmedetomidine drip was infused to the patient 15 minutes after surgery, and the

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18-60 years patients candidate for orthognathic surgery Consent to participate in the study

Exclusion criteria

Exclusion criteria: Uncontrolled diabetes Uncontrolled blood pressure Glaucoma disease Any allergy to antihistamines Opiods drug adiction

Design outcomes

Primary

Measure	Time frame
Severity of postoperative agitation. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Ramsy sedation Scale.;Severity of postoperative pain. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Visual Analogue Scale.;Hemodynamic changes. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Blood pressure and Heart Rate.	—

Measure

Time frame

Severity of postoperative agitation. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Ramsy sedation Scale.;Severity of postoperative pain. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Visual Analogue Scale.;Hemodynamic changes. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Blood pressure and Heart Rate.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Khajavi

Tehran University of Medical Sciences

khajavim@tums.ac.ir+98 21 6312 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026