Heparin thrapy in brain dead patients

Measurement of blood levels of D-dimer and CRP in brain dead patients and the effect of heparin with therapeutic dose on early renal and hepatic function of these organs in brain dead patients

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130304012695N16

Enrollment

Registered

2023-04-17

Start date

2021-04-09

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Brain dead. Condition 2: Thrombophilia. Other specified disorders of central nervous system Other thrombophilia

Interventions

Intervention 1: Intervention group: After the confirmation of brain death of the patients and their family's consent to organ donation, first blood samples were measured to check CRP and D-dimer and 5

Eligibility

Sex/Gender

All

Age

10 Years to 60 Years

Inclusion criteria

Inclusion criteria: Brain death patients in the ages of 10 to 60 years Renal failure patients undergoing dialysis on the transplant list Liver failure patients on the transplant list Brain death patients with D-dimer more than 500ng/ml Brain death patients with CRP greater than 20mg/L

Exclusion criteria

Exclusion criteria: Brain death patients who have Cr=2.5 mg/dl. Renal failure patients who did not have a history of previous successful transplantation Liver failure patients who did not have a history of previous successful transplantation

Design outcomes

Primary

Measure	Time frame
Serum urea and creatinine of kidney transplant recipients. Timepoint: At the beginning of the patient's entry into the study and then daily until 7 days after transplantation. Method of measurement: By sending patients' blood samples to the laboratory.;Measurement of liver enzymes and bilirubin in liver transplant recipients. Timepoint: At the beginning of the patient's entry into the study and then daily until 7 days after transplantation. Method of measurement: By sending patients' blood samples to the laboratory.;Measurement of D-dimer in brain death patients. Timepoint: Once and 24 hours before organ donation. Method of measurement: By sending patients' blood samples to the laboratory.;Measurement of CRP in the blood of brain dead patients. Timepoint: Once and 24 hours before organ donation. Method of measurement: By sending patients' blood samples to the laboratory.	—

Measure

Time frame

Serum urea and creatinine of kidney transplant recipients. Timepoint: At the beginning of the patient's entry into the study and then daily until 7 days after transplantation. Method of measurement: By sending patients' blood samples to the laboratory.;Measurement of liver enzymes and bilirubin in liver transplant recipients. Timepoint: At the beginning of the patient's entry into the study and then daily until 7 days after transplantation. Method of measurement: By sending patients' blood samples to the laboratory.;Measurement of D-dimer in brain death patients. Timepoint: Once and 24 hours before organ donation. Method of measurement: By sending patients' blood samples to the laboratory.;Measurement of CRP in the blood of brain dead patients. Timepoint: Once and 24 hours before organ donation. Method of measurement: By sending patients' blood samples to the laboratory.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Khajavi

Tehran University of Medical Sciences

KHAGAVIM@TUMS.AC.IR+98 21 6312 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026