Comparison of Diphenhydramine injection at wound edge and lidocaine In reducing pain after open kidney surgery

Infiltration of Diphenhydramine versus subcutaneous Lidocaine at the wound site to reduce pain after open renal surgeries

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130304012695N13

Enrollment

Registered

2022-07-08

Start date

2022-07-11

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

local anesthetic effect of diphenhydramine.

Interventions

Intervention 1: Intervention group: 10 ml of normal saline, which contains Diphenhydramine (rahapharm company )10 milligrams per milliliter, is prepared with the help of an anesthesiologist according

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients who have the consent to participate in the study Patients who are candidates for open kidney surgery

Exclusion criteria

Exclusion criteria: History of allergies to the drugs used History of sleep Apnea History of addiction to drugs or other psychotropic substances History of acute drug or alcohol poisoning History of psychological disorder

Design outcomes

Primary

Measure	Time frame
Acute Postoperative Pain. Timepoint: In recovery room and 1,6,12,18 and 24 hours after surgery. Method of measurement: Visual Analog Scale(VAS score).;Agitation and Sedation degree. Timepoint: In recovery room and 1,6,12,18 and 24 hours after surgery. Method of measurement: Ramsy Sedation Scale.;When was the first need for analgesics. Timepoint: During 6 hours after surgery. Method of measurement: In terms of time per minute, and according to the first time after extubation of patients, the analgesic is injected.;Total analgesics consumption during the first 24 hr after surgery. Timepoint: One time at the end of the first 24 hours after operation. Method of measurement: According to the patient file and nursing report.	—

Measure

Time frame

Acute Postoperative Pain. Timepoint: In recovery room and 1,6,12,18 and 24 hours after surgery. Method of measurement: Visual Analog Scale(VAS score).;Agitation and Sedation degree. Timepoint: In recovery room and 1,6,12,18 and 24 hours after surgery. Method of measurement: Ramsy Sedation Scale.;When was the first need for analgesics. Timepoint: During 6 hours after surgery. Method of measurement: In terms of time per minute, and according to the first time after extubation of patients, the analgesic is injected.;Total analgesics consumption during the first 24 hr after surgery. Timepoint: One time at the end of the first 24 hours after operation. Method of measurement: According to the patient file and nursing report.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Khajavi

Tehran University of Medical Sciences

khajavim@tums.ac.ir+98 21 6312 1220

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026