Poor ovarian Responders. Other ovarian dysfunction
Conditions
Interventions
Intervention 1: Intervention group:
Agonist (3-2 days after onset of LD cycles lasting 21-14 days, take one tablet daily for 21 days and the cycle Busereline 500 µg (Super facts) will subcutaneously.
Treatment - Drugs
Intervention group:
Agonist (3-2 days after onset of LD cycles lasting 21-14 days, take one tablet daily for 21 days and the cycle Busereline 500 µg (Super facts) will subcutaneously. Later down regu
Control group:
Antagonist (GnRH when the follicle diameter 10mm, reach to daily injections of HCG, Cetrorelix 0.25 mg subcutaneously daily will)
Sponsors
Vice Chancellor for Research and Technology, Babol University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
37 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Infertile women who underwent IVF process and poor ovarian response; The number of oocytes recovered in less than 5; Serum estradiol levels on the day of HCG injection is less than pg / ml 600; Serum FSH levels in Male than 3 mIU / ml 12; Has over 37 years of age; Cessation of ovarian cycles due to poor response. Exclusion criteria: Chronic diseases; Diabetes; Any endocrine disease; Submucosal polyps; Leiomyoma and uterine septum.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy. Timepoint: 7-6 weeks to see the gestational sac. Method of measurement: Ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial thickness. Timepoint: Day of HCG injection. Method of measurement: Ultrasound.;Estradiol levels. Timepoint: Day of HCG injection. Method of measurement: Ultrasound.;The number of oocytes recovered. Timepoint: Day puncture. Method of measurement: Laboratory.;The duration of ovarian stimulation. Timepoint: Duration of drug use. Method of measurement: Clinical.;No. of fertilized oocytes. Timepoint: Day of embryo transfer. Method of measurement: Laboratory.;The amount of transferred embryos. Timepoint: Day of embryo transfer. Method of measurement: Laboratory.;The number of canceled cycles. Timepoint: Before embryo transfer. Method of measurement: Clinical.;Pregnancy than to transfer. Timepoint: 16 days after embryo transfer. Method of measurement: Laboratory.;The incidence of ovarian hyperstimulation syndrome (OHSS). Timepoint: After puncture. Method of measurement: Clinical & Laboratory.;The total amount of FSH. Timepoint: 48 hours before puncture. Method of measurement: Laboratory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNargess Gholizadeh Pasha
Fatemehzahra Fertility & reproductive Health Reseach Center
Outcome results
None listed