Condition 1: Calculus of gallbladder with acute cholecystitis. Condition 2: Anesthesia for appendectomy. Condition 3: Ventral hernia without obstruction or gangrene. Condition 4: Unilateral or unspecified inguinal hernia, without obstruction or gangrene. Condition 5: Abnormal uterine and vaginal bleeding, unspecified. Condition 6: Fracture of neck of femur. Condition 7: Fracture of lower leg, including ankle. Condition 8: Fracture of upper limb, level unspecified. Calculus of gallbladder with a
Conditions
Interventions
Intervention 1: In control group, premedication will be Fentanyl (1 µg/kg) and midazolam 0.05 mg/kg.
Induction of anesthesia is intravenous propofol with dose of 1.5 mg/kg
Maintenance of anesthesia wi
Treatment - Drugs
In control group, premedication will be Fentanyl (1 µg/kg) and midazolam 0.05 mg/kg.
Induction of anesthesia is intravenous propofol with dose of 1.5 mg/kg
Maintenance of anesthesia will be performe
In intervention group premedication is Fentanyl (1 µg/kg) and midazolam 0.05 mg/kg.
Induction of anesthesia is intravenous propofol with dose of 1.5 mg/kg
Maintenance of anesthesia intravenous propo
Sponsors
Deputy of research, Shahroud University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:Man or woman with 18 to 50 years old;an anesthesia risk of 1 or 2 (According to American society of anesthesiologist's classification); orthopedic or reconstructive operations on extremities; hip and pelvic operations;Inguinal hernioraphy; abdominal hernioraphy; cholecystectomy; appendectomy. Exclusion criteria: Patients with a history of opiates or alcohol abuse; sedative and anticonvulsive therapy; anesthesia or surgical complications during operation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BIS (Depth of anesthesia). Timepoint: Every 5 minutes during operation. Method of measurement: By using Danmeter’s Cerebral State Monitor (Model CSM2) and record BIS index as an exact number from 0 to 100 every 5 minutes.;Heart rate. Timepoint: before procedure and every 5 minutes during operation. Method of measurement: Novin saadat's cardiac monitoring and record as beat per minute.;Systolic blood pressure. Timepoint: before procedure and every 5 minutes during operation. Method of measurement: Novin saadat's automatic Non invasive BP monitoring and record as mmHg.;Pupil's reflex. Timepoint: Every 5 minutes during operation. Method of measurement: Clinical observation and chart as Yes or No.;Pupil's size. Timepoint: every 5 minutes during procedure. Method of measurement: Clinical observation and chart as an exact number from 1 to 10 (milimeter).;Sweating. Timepoint: Every 5 minutes during operation. Method of measurement: Clinical observation and chart as Yes or No. | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative agitation. Timepoint: Every 5 minutes during recovery. Method of measurement: Clinical observation and chart as Yes or No.;Postoperative nausea and vomiting. Timepoint: Every 5 minutes during recovery. Method of measurement: Clinical observation and chart as Yes or No.;Recovery time. Timepoint: Every 5 minutes during recovery. Method of measurement: The end of recovery will be determined by Modified Alderet scoring system (MASS). In this system, scoring 9 points in 5 variables of consciousness, circulation (systemic blood pressure), breathing, SPO2, and activity, each of 2 points, specifies the end of recovery.;Postoperative pain. Timepoint: Every 5 minutes during recovery. Method of measurement: Clinical observation and chart as Yes or No.;Anesthesia cost. Timepoint: Time of discharge. Method of measurement: Total drug's (Isoflurane or Propofol) cost in Rial. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactJavad Nourian MD
Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran
Outcome results
None listed