Elderly.
Conditions
Interventions
Intervention group: Group 1 receives the probiotic-enriched kefir drinks. Group 2 receives the kefir drink..
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Willingness to participate in the study Male gender Age over 65 years Body mass index above 25 Absence of chronic liver, kidney, diabetes, cardiovascular diseases, digestive disorders, chronic infectious diseases, severe neurological and psychological disorders and not taking antidepressants medicine Not taking probiotic supplements within 2 months and antibiotics within the last 3 months Not taking antioxidant supplements Not regularly consuming alcohol (more than three units per week) and smoking
Exclusion criteria
Exclusion criteria: Any changes in diet or medications Unwillingness to continue studying Unwanted side effects that improve by stopping the intervention, which will cause participants to withdraw from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total antioxidant capacity. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Calorimetric method with Zelbio (Germany) kit with microplate reader device.;Superoxide dismutase. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Calorimetric method with Zelbio (Germany) kit with microplate reader device.;Catalase. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Calorimetric method with Zelbio (Germany) kit with microplate reader device.;Glutathione peroxidase. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Calorimetric method with Zelbio (Germany) kit with microplate reader device.;C-reactive protein. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) method with LDN (Germany) kit.;Malondialdehyde. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Spectrophotometry method with Zelbio (Germany) kit.;Interleukin-6. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) method with LDN (Germany) kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Scales.;Height. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Non stretchable meter.;Waist Circumference. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Non stretchable meter.;Hip Circumference. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Non stretchable meter.;Lipid profiles. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Commercial kits using an automatic autoanalyzer.;Appetite score. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Visual appetite scale.;Depression score. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Geriatric depression scale-15. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehran Nouri
Shiraz University of Medical Sciences
Outcome results
None listed