methamphetamine dependence. mental and behavioral disorders due to use of other stimulants, dependence syndrome
Conditions
Interventions
Intervention 1: Capsules Topiramate50 mg/dayfor the first week, 100 mg/day for the second week and then 200 mg/day for remaining 0 weeks. Intervention 2: placebo for 10 weeks.
Treatment - Drugs
Placebo
Capsules Topiramate50 mg/dayfor the first week, 100 mg/day for the second week and then 200 mg/day for remaining 0 weeks
Sponsors
Vice chancellor for research, Kurdistan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria:Diagnosis of Methamphetamine dependence based on DSM-IV-TR ; Positive methamphetamine urinary test at the beginning of the study; age between 18-65 Exclusion Criteria: any other mental disorder on axis I except for depression;Any serious medical or neurological problem ,2- IQ <70; abusing other substances except for nicotine and methadone; history of Attention Defecit-Hyperactivity Disorder during childhood ; pregnancy and breast feeding; development of psychotic symptoms requiried pharmacotherapy; serious suicidal ideations
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Craving. Timepoint: Baseline and then weekly. Method of measurement: visual analogue craving scale.;Addiction severity. Timepoint: Baseline and at the end of the study. Method of measurement: by Addiction SeverityIndex.;Rate of use. Timepoint: Baseline and then weekly. Method of measurement: Urinary methamphetamine test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Farzin Rezaei
Kurdistan University of Medical Sciences
Outcome results
None listed