Evaluation blood level of anti-m?llerian hormone measurement efficiency in prediction of the response to weight loss diet in obese women with polycystic ovarian syndrome with infertility problem.

Evaluation of anti-m?llerian hormone levels as a predictive factor of response to weight loss treatment in obese infertile women with PCOS.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201302241141N14

Enrollment

Registered

2013-07-06

Start date

2012-10-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity in polycystic ovary syndrome women. Polycystic ovarian syndrome

Interventions

Intervention group:weight loss diet for 12 weeks.

Treatment - Other

Intervention group:weight loss diet for 12 weeks

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1-Diagnosis of PCOS, according to the Rotterdam Consensus Workshop Group, by 2 of the following 3 criteria: •Menstrual irregularity (cycle length31 d or variation between consecutive cycles of >3 d); •Clinical (hirsutism assessed by a Ferriman-Gallwey score > 8) or biochemical [free androgen index (FAI) > 5.4 or testosterone_1.4 nmol/L] hyperandrogenism; •Positive ultrasound presentation of polycystic ovaries by transvaginal scan (More than 12 follicles 9-2 mm and increased ovarian volume greater than 10 cm3) . 2-Age between 18 -40 years old. Exclusion criteria: 1.Body mass index (BMI; in kg/m2) < 30. 2.Type 2 diabetes mellitus. 3. Related endocrine disorders [identified by assessment of thyroid-stimulating hormone (TSH), prolactin, and 17_hydroxyprogesterone]. 4.The use of medications affecting the hypothalamus - pituitary - ovarian axis and insulin-sensitizing agents (metformin) is not permitted during the study phase and 12 wk before commencement of the study phase. Also, the use of oral contraceptives is not permitted during and 4 wk before commencement of the study phase. 5.Cases of alcoholism and smoking. 6.Regular exercise activities during the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
AMH serum level. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory (ELISA method).	—

Secondary

Measure	Time frame
FSH serum level. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;LH serum level. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;PRL serum level. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;Androgens serum level. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;Sex hormone–binding globulin (SHBG) serum level. Timepoint: Before and 12 weeks after e starting the diet. Method of measurement: Laboratory kits.;Free Androgen Index serum level (FAI). Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;Insulin Resistance (IR) indices. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;Fasting insulin. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.	—

Measure

Time frame

FSH serum level. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;LH serum level. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;PRL serum level. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;Androgens serum level. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;Sex hormone–binding globulin (SHBG) serum level. Timepoint: Before and 12 weeks after e starting the diet. Method of measurement: Laboratory kits.;Free Androgen Index serum level (FAI). Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;Insulin Resistance (IR) indices. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.;Fasting insulin. Timepoint: Before and 12 weeks after starting the diet. Method of measurement: Laboratory kits.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactArezoo Arabipoor

Royan institute

Arezoo.arabipoor@gmail.com+98 21 2356 2640

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026