Laparoscopic cholecystectomy. Calculus of gallbladder without cholecystitis
Conditions
Interventions
Intervention 1: In the intervention group before induction of anesthesia, infusion of 50 mg/kg of body weigth magnesium sulfate in 100 cc of normal saline over 10 minutes. Intervention 2: In the plas
Prevention
Placebo
In the intervention group before induction of anesthesia, infusion of 50 mg/kg of body weigth magnesium sulfate in 100 cc of normal saline over 10 minutes.
In the plasebo group and for blining of patients and observers before induction of anesthesia 100 ml of normal saline will be infused intravenously in 10 min.
Sponsors
Research Deputy of Medicine Faculty, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: consent to participate in research projects - patients scheduled for surgery of laparoscopic cholecystectomy with pneumoperitoneum gas CO2 - Age 70-20 years - physical patients with class ASA I-II . Exclusion criteria: chronic use of drugs beta-adrenergic and calcium-channel blockers - drugs, psychotropic substances, use of lithium, other drugs such as hemodynamic TCA - history of cardiovascular diseases - sensitivity to magnesium sulfate - diseases such as hypertension, diabetes mellitus, renal disease, acute cholecystitis and endocrine or metabolic disease. Cases who develope complications also would be excluded. Also conversion of laparoscopic cholecystectomy to open surgery because of technical problems.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial blood pressure. Timepoint: Before and after induction, before pneumoperitoneum, and every 10 minutes after pneumoperitoneum and after surgery. Method of measurement: Will be recorded by Automatic Hemodynamic Monitoring.;Heart Rate. Timepoint: Before and after induction, before pneumoperitoneum, and every 10 minutes until 60 minutes after pneumoperitoneum and after surgery. Method of measurement: Will be recorded by Automatic Hemodynamic Monitoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of usage of Propofol. Timepoint: One time at the end of surgery. Method of measurement: The mean dose per kilogram of body weight per minute.;Sedation quality of the patient in recovery. Timepoint: Every 15 minutes. Method of measurement: Clinical evaluation using Ramsay sedation score system.;Patient's pain acuty during recovery. Timepoint: Every 15 minutes. Method of measurement: According to VAS rating score.;TNG consumption rate. Timepoint: End of study. Method of measurement: Measuring amount of consumed drug. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Mougouee MD.
Tehran University of Medical Science
Outcome results
None listed