Metabolic Syndrome. Metabolic Syndrome
Conditions
Interventions
Intervention 1: Intervention phase: A blend of canola oil and Pistacia Atlantica seed oil (canola-Pistacia Atlantica seed oil). Intervention 2: Intervention phase: canola–corn oil with TBHQ. Intervent
Sponsors
Yazd University of Medical Sciences
Neshatavar Food Industry (DATIS)
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Adults aged 20-50 years Diagnosed with metabolic syndrome (having at least three of these conditions): abdominal obesity (waist circumference >102 cm in men and >88 cm in women), high blood pressure (systolic blood pressure >130 mmHg or diastolic blood pressure >85 mmHg), low serum high-density lipoprotein cholesterol (serum HDL cholesterol 150 mg/dl), high blood glucose (fasting blood glucose = 100 mg/dl)
Exclusion criteria
Exclusion criteria: Diagnosis or reporting a history of cardiovascular disease Diagnosis or reporting a history of diabetes mellitus Diagnosis or reporting a history of cancer Diagnosis or reporting a history of pancreatitis Diagnosis or reporting a history of liver disease Diagnosis or reporting a history of kidney disease Changing the blood sugar and lipid-lowering medications over the past three months Taking systemic corticosteroids, androgen, phenytoin, erythromycin, Hemostatic regulators (other than aspirin), gastrointestinal medicine less than 30 days before enrollment History of gastrointestinal disorders Alcohol use Being pregnant Intention to become pregnant Giving birth in the last 12 months Having allergy or intolerance to the intervention oils Reluctance to follow the study protocol Having weight change over 3 kg two months prior to the study Taking Omega-3 supplements more than 1 g/day Smoking more than 20 cigarettes a day Taking drugs for COVID-19 including remdesivir, Interferon, actemra, favipiravir in the last 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum total antioxidant capacity (TAC). Timepoint: Start and end of each intervention period. Method of measurement: IU/ml.;Serum myeloperoxidase (MPO). Timepoint: Start and end of each intervention period. Method of measurement: ng/ml.;Serum malondialdehyde (MDA). Timepoint: Start and end of each intervention period. Method of measurement: nmol to ml.;Serum total oxidant status (TOS). Timepoint: Start and end of each intervention period. Method of measurement: IU/ml.;Serum superoxide Dismutase (SOD). Timepoint: Start and end of each intervention period. Method of measurement: IU/ml.;Serum catalase (CAT). Timepoint: Start and end of each intervention period. Method of measurement: IU/ml.;Serum glutathione peroxidase (GPX). Timepoint: Start and end of each intervention period. Method of measurement: IU/ml.;Serum glutathione reductase (GR). Timepoint: Start and end of each intervention period. Method of measurement: U/gr Hb.;Serum nitric oxide (NO). Timepoint: Start and end of each intervention period. Method of measurement: Mm/ml.;Fasting serum glucose. Timepoint: Start and end of each intervention period. Method of measurement: using appropriate kits.;Serum triglycerides. Timepoint: Start and end of each intervention period. Method of measurement: mg/dL.;Serum high density lipoprotein cholesterol (HDL-C). Timepoint: Start and end of each intervention period. Method of measurement: mg/dL.;Systolic blood pressure. Timepoint: Start and end of each intervention period. Method of measurement: Barometer.;Diastolic blood pressure. Timepoint: At the start and end of each intervention period. Method of measurement: Barometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mass index (BMI). Timepoint: Start and end of each intervention. Method of measurement: kg/m2.;Body fat percent. Timepoint: Start and end of each intervention. Method of measurement: Body composition analyzer.;Body muscle percent. Timepoint: Start and end of each intervention. Method of measurement: Body composition analyzer.;Body weight. Timepoint: Start and end of each intervention. Method of measurement: Body composition analyzer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBahareh Sasanfar
Yazd University of Medical Sciences
Outcome results
None listed