Skin Wound. Open wound of unspecified body region
Conditions
Interventions
Intervention 1: Intervention 1: Coverage of the skin graft donor site with acellular amnion loaded with cultured fetal fibroblast cell. The dressing will be changed every other day till complete heali
Treatment - Other
Intervention 1: Coverage of the skin graft donor site with acellular amnion loaded with cultured fetal fibroblast cell. The dressing will be changed every other day till complete healing of the wound
Intervention 2: Coverage of the skin graft donor site with acellular amnion. The dressing will be changed every other day till complete healing of the wound after 3 days.
Control group: Coverage of the skin graft donor site with Vaseline gauze. The dressing will be changed every other day till complete healing of the wound after 3 days.
Sponsors
Vice chancellor for research of Tehran University of Medical
Eligibility
Sex/Gender
All
Age
8 Years to 60 Years
Inclusion criteria
Inclusion criteria: Laboratory inclusion criteria: 1. Pregnant women who are older than 18 years old that had to be aborted 2. Filling informed consent 3. Aborted fetus with the age of 11 to 14 weeks 4.Lack of infectious diseases (HIV-HBV-HCV) 5.Lack consumption of immune-suppressive and cytotoxic drugs during past 6 months Laboratory exclusion criteria: 1. Aborted fetus that is younger than 11 weeks or older than 14 weeks 2.Pregnant women who are younger than 18 years old Clinical inclusion criteria: 1.Patients with the age of 20 to 60 years old 2. Those who need skin graft surgery 3.The extent of surgical site wound 10-30% 4. Filling informed consent 5. Lack of co-morbidity Clinical exclusion criteria: 1.Under the age of 20 years and above 60 years 2.The extent of surgical site wound more than 30% and less than 10% 3.Lack of informed consent
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound healing. Timepoint: Examination and photography on 3, 5, 7, 11, 13 and 15 days and 1 month after surgery - biopsy on 7 day? after surgery. Method of measurement: Observation and Examination and Biopsy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: Three, five, seven, nine, eleven, thirteen and fifteen days after surgery. Method of measurement: Visual Analogue Scale.;Infection. Timepoint: Seven and fifteen days after surgery. Method of measurement: Examination, Wound Culture.;Scar. Timepoint: Three and six months after surgery. Method of measurement: Vancouver Scar Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Javad Fatemi
Hazrat Fatima hospital
Outcome results
None listed