Acute lymphocytic leukemia. Acute lymphoblastic leukaemia [ALL]
Conditions
Interventions
Intervention 1: Prescription of Palifermin (IV) in case group by children oncologist 3 days before & after chemotherapy protocol with 60mc/kg/day dosage would be performed. Intervention 2: In control
Prevention
Prescription of Palifermin (IV) in case group by children oncologist 3 days before & after chemotherapy protocol with 60mc/kg/day dosage would be performed.
In control group, patiens would rinse Chlorhexidin mouth wash from 3 days before chemotherapy for 2 weeks, two time per day (morning & evening) and 1 minute per time of use.
Sponsors
Vice chancellor for research, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
5 Years to 15 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: children within range of 5-15 years old hospitalizing in oncology ward of Tabriz children hospital undergoing chemotherapy due to ALL. Exclusion criteria: patients who have other systemic diseases; existence of any oral ulcers or mucositis before the beginning chemotherapy; experience of dermo-respiratory sensitivity.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mucositis. Timepoint: 1& 2 weeks after chemotherapy. Method of measurement: Index of WHO. | — |
Secondary
| Measure | Time frame |
|---|---|
| Allergy to drugs. Timepoint: One day after drug prescription for one month. Method of measurement: Clinical examination.;Hyperkeratosis. Timepoint: One day after drug prescription for one month. Method of measurement: Clinical examination.;Altered taste. Timepoint: One day after drug prescription for one month. Method of measurement: patient's symptoms.;Increase in the thickness in the tongue. Timepoint: One day after drug prescription for one month. Method of measurement: Clinical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNarges Gholizadeh
Tabriz University of Medical Sciences
Outcome results
None listed