Clinical and bacteriological Effects of Synbiotic as an Adjunct in Phase I Periodontal Therapy

Analysis of the clinical and bacteriological effects scailing and root planing with assumption of synbiotic product or placebo as the complementary treatment in patients with chronic periodontitis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130216012487N7

Enrollment

Registered

2020-11-22

Start date

2017-11-06

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention group: Dissolve 1 sachet synbiotic Product in 30ml water and use it as mouthwash twice a day after tooth brushing. Intervention 2: Control group: Dissolve 1 sachet of plac

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient with complete physical and mental health Who were not treated for periodontitis during the last two years Who did not use probiotic food products during the past year Who have at least 10 to 12 areas with the pocket depth of 3mm to 6 mm with bleeding on probing.

Exclusion criteria

Exclusion criteria: subjects with history of uncontrolled diabetes, AIDS, rheumatic fever, severe hepatic and renal problems, deficiency in immunological and neurological systems patients consuming any type of medicine that affect periodontal tissue (Phenytoin, Cyclosporine and Nifedipine) pregnant and lactating women smokers and alcoholic subjects subjects with a pocket depth of more than 6 mm

Design outcomes

Primary

Measure	Time frame
Count of Porphyromonas gingivalis in subgingival plaque. Timepoint: At baseline and 30 days after intervention. Method of measurement: Dilution and culture of bactery samples in riched solid blood agar and black pigmentation of Porphyromonas gingivalis visual colony counting and microscopic experiments for detection of the gram negative bacillus of Porphyromonas gingivalis and biochemical tests.	—

Secondary

Measure	Time frame
Measuring pocket depth. Timepoint: At baseline and 30 days after intervention. Method of measurement: Measuring of pocket depth in mm by a University of Michigan probe with Wiliams markings.;Measuring clinical attachment loss. Timepoint: At baseline and 30 days after intervention. Method of measurement: Measuring of clinical attachment loss in mm by University of Michigan with Wiliams markings probe.;Evaluation of bleeding on probing. Timepoint: At baseline and 30 days after intervention. Method of measurement: Probing by University of Michigan with Wiliams markings probe and then clinical absevation.	—

Measure

Time frame

Measuring pocket depth. Timepoint: At baseline and 30 days after intervention. Method of measurement: Measuring of pocket depth in mm by a University of Michigan probe with Wiliams markings.;Measuring clinical attachment loss. Timepoint: At baseline and 30 days after intervention. Method of measurement: Measuring of clinical attachment loss in mm by University of Michigan with Wiliams markings probe.;Evaluation of bleeding on probing. Timepoint: At baseline and 30 days after intervention. Method of measurement: Probing by University of Michigan with Wiliams markings probe and then clinical absevation.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShirin amini

Dental School, Isfahan Branch, Islamic Azad University

Sh.amini@khuisf.ac.ir+98 31 1535 4053

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026