the effects of capsules containing probiotics on diabetic retinopathy

The effect of probiotic food supplement on metabolic parameters, oxidative stress and clinical symptoms in patients with diabetic retinopathy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130211012438N29

Enrollment

Registered

2019-01-26

Start date

2018-05-20

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic retinopathy. Diabetic retinopathy

Interventions

Intervention 1: Intervention group: probiotic capsule ,One number per day for 12 weeks orally. Intervention 2: Control group: placebo capsule ,One number per day for 12 weeks orally.

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Have each stage of diabetis retinopathy Normal intraocular pressure

Exclusion criteria

Exclusion criteria: Corneal opacity Intra-vitreous hemorrhage of the retina, with the exception of diabetic retinopathy Glaucoma disease or high refractive errors History of any previous retinal treatment Other diseases of the retina and optic nerve Ocular hypertension

Design outcomes

Primary

Measure	Time frame
Visual Acuity. Timepoint: At the beginning of the study and three months after the start of the study. Method of measurement: Visual Acuity check with snellen chart.;HOMA-IR. Timepoint: At the beginning of the study and three months after the start of the study. Method of measurement: Standard formula.;Macular thickness. Timepoint: At the beginning of the study and three months after the start of the study. Method of measurement: Central Macular Thickness Evaluate with OCT Instrument.	—

Measure

Time frame

Visual Acuity. Timepoint: At the beginning of the study and three months after the start of the study. Method of measurement: Visual Acuity check with snellen chart.;HOMA-IR. Timepoint: At the beginning of the study and three months after the start of the study. Method of measurement: Standard formula.;Macular thickness. Timepoint: At the beginning of the study and three months after the start of the study. Method of measurement: Central Macular Thickness Evaluate with OCT Instrument.

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Secondary

Measure	Time frame
Total Anti Oxidant (TAC). Timepoint: At the beginning and the end of the study. Method of measurement: Photospectrometry.;Glutathion. Timepoint: At the beginning and the end of the study. Method of measurement: Photospectrometry.;Malondialdehyde. Timepoint: At the beginning and the end of the study. Method of measurement: Photospectrometry.;Nitric oxide. Timepoint: At the beginning and the end of the study. Method of measurement: Photospectrometry.;High sensitive-C reactive protein(hs-CRP). Timepoint: At the beginning and the end of the study. Method of measurement: ELISA.;HbA1C. Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Fasting plasma glucose. Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Insulin. Timepoint: At the beginning and the end of the study. Method of measurement: ELISA.;Triglyceride. Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Total cholesterol. Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Very low density lipoprotein-cholesterol (VLDL-ch). Timepoint: At the beginning and the end of the study. Method of measurement: Standard formula.;High density lipoprotein-cholesterol (HDL-ch). Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Low density lipoprotein-cholesterol (VLDL-ch). Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;QUICKI. Timepoint: At the beginning and the end of the study. Method of measurement: Standard formula.	—

Measure

Time frame

Total Anti Oxidant (TAC). Timepoint: At the beginning and the end of the study. Method of measurement: Photospectrometry.;Glutathion. Timepoint: At the beginning and the end of the study. Method of measurement: Photospectrometry.;Malondialdehyde. Timepoint: At the beginning and the end of the study. Method of measurement: Photospectrometry.;Nitric oxide. Timepoint: At the beginning and the end of the study. Method of measurement: Photospectrometry.;High sensitive-C reactive protein(hs-CRP). Timepoint: At the beginning and the end of the study. Method of measurement: ELISA.;HbA1C. Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Fasting plasma glucose. Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Insulin. Timepoint: At the beginning and the end of the study. Method of measurement: ELISA.;Triglyceride. Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Total cholesterol. Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Very low density lipoprotein-cholesterol (VLDL-ch). Timepoint: At the beginning and the end of the study. Method of measurement: Standard formula.;High density lipoprotein-cholesterol (HDL-ch). Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;Low density lipoprotein-cholesterol (VLDL-ch). Timepoint: At the beginning and the end of the study. Method of measurement: Enzymatic Kits.;QUICKI. Timepoint: At the beginning and the end of the study. Method of measurement: Standard formula.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHasan Farajipoor

Kashan University of Medical Sciences

farajipoor_h@kaums.ac.ir+98 31 5554 0021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 8, 2026