The effect of vitamin E and metformin on fat

The evaluation of the effect of vitamin E and metformin on fatty liver in obese children

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013021012421N1

Enrollment

104

Registered

2013-05-05

Start date

2012-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non alcoholic fatty liver. fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Metformin 500mg tab bd. Intervention 2: Metformin 500mg tab tds. Intervention 3: vitamin E 400 unit pearl daily. Intervention 4: vitamin E 400 unit pearl bd.

Treatment - Drugs

Metformin 500mg tab bd

Metformin 500mg tab tds

vitamin E 400 unit pearl daily

vitamin E 400 unit pearl bd

Eligibility

Sex/Gender

All

Age

4 Years to 18 Years

Inclusion criteria

Inclusion criteria: Inclusion criterion: presence of fatty liver. Exclusion criteria: alcoholism; another chronic disease such as viral hepatitis.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Liver ecogenicity. Timepoint: before and 2 months after the intervention and end of intervention (four months after intervention). Method of measurement: sonography.	—

Secondary

Measure	Time frame
BMI. Timepoint: before and 2 months after the intervention and end of intervention (four months after intervention). Method of measurement: balance and height messuring instruments.	—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026