patients admitted in Intensive Care Unit.
Conditions
Interventions
Intervention 1: alfa-lipoic acid 900mg/day for 10 days. Intervention 2: placebo for 10 days.
Treatment - Drugs
Placebo
alfa-lipoic acid 900mg/day for 10 days
placebo for 10 days
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: age=18; expected length of stay more than 7 days; using enteral feeding method during admitted to ICU. Exclusion criteria: having the history of autoimmune disease, severe renal or liver failure, AIDS, hepatitis; having severe malnutrition at the admission time; having TPN at the admission time in ICU; extreme intolerance to enteral feeding.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of stay in ICU. Timepoint: at the end. Method of measurement: days.;Mortality. Timepoint: at the end. Method of measurement: number and percent.;Ventilator free days. Timepoint: during ICU stay. Method of measurement: daily assessment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin resistance. Timepoint: first and last days of intervention. Method of measurement: HOMA calculation equation.;Sequential organ failure assessment score. Timepoint: first and last days of intervention. Method of measurement: sequential organ failure assessment score questioniar.;Malondialdehyde. Timepoint: first and last days of intervention. Method of measurement: spectrophotometery.;Total antioxidant capacity. Timepoint: first and last days of intervention. Method of measurement: ELIZA.;C reactive protein. Timepoint: first and last days of intervention. Method of measurement: nephelometry.;Interleukin-6. Timepoint: first and last days of intervention. Method of measurement: ELIZA.;Albumin. Timepoint: first and last days of intervention. Method of measurement: ELIZA.;PreAlbumin. Timepoint: first and last days of intervention. Method of measurement: Turbidimetry.;Total lymphocyte count. Timepoint: first and last days of intervention. Method of measurement: microscopic count.;Mid arm circumference. Timepoint: first and last days of intervention. Method of measurement: centimeter.;Total protein. Timepoint: first and last days of intervention. Method of measurement: based on labratory measurement. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactnajmeh hejazi
shiraz university of medical sciences- nutrition department
Outcome results
None listed