The effect of omega-3 fatty acids on the treatment of acute lung injury

The effect of addition of omega-3 fatty acids on the standard treatment of critical ill patients with acute lung injury on mortality rate compared to standard treatment in intensive care unit

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013020612387N1

Enrollment

Registered

2013-08-28

Start date

2012-11-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute lung injury. Acute respiratory failure

Interventions

Intervention 1: Intervention group: Standard treatment with omega 3 capsules gavage, 6 capsules daily (2 capsules TDS) for 14 days. Intervention 2: Control group: ALI standard treatment (low tid

Treatment - Drugs

Treatment - Other

Intervention group: Standard treatment with omega 3 capsules gavage, 6 capsules daily (2 capsules TDS) for 14 days.

Control group: ALI standard treatment (low tidal volume strategy,VT:6 ml/kg)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with ALI criteria (Pao2/Fio2400, renal or liver failure, history of frequent transfusions, Thrombocytopenia (PLT<80000), Leukopenia (WBC<3000).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pao2/Fio2. Timepoint: On admission, seventh and fourteenth days. Method of measurement: Oxygenation, lung mechanic and inflammatory factors.	—

Secondary

Measure	Time frame
Ventilator free days. Timepoint: On admission, seventh and fourteenth days. Method of measurement: Air way compliance and resistance is recorded.;Neutrophil peroxidation activity. Timepoint: On admission, seventh and fourteenth days. Method of measurement: After performing Mini- BAL, the fluid will be centrifuged and the debris will be removed. To measure the activity of neutrophil peroxidation, a marker of lung injury, the fluid will be sent to the laboratory.;Number of organ failure. Timepoint: On admission, seventh and fourteenth days. Method of measurement: Evaluation of various parameters such as clinical and blood serum factors.	—

Measure

Time frame

Ventilator free days. Timepoint: On admission, seventh and fourteenth days. Method of measurement: Air way compliance and resistance is recorded.;Neutrophil peroxidation activity. Timepoint: On admission, seventh and fourteenth days. Method of measurement: After performing Mini- BAL, the fluid will be centrifuged and the debris will be removed. To measure the activity of neutrophil peroxidation, a marker of lung injury, the fluid will be sent to the laboratory.;Number of organ failure. Timepoint: On admission, seventh and fourteenth days. Method of measurement: Evaluation of various parameters such as clinical and blood serum factors.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoud Parish

Tabriz University of Medical Sciences

masoudparish@yahoo.com+98 411385111417

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026