Condition 1: Heart failure. Condition 2: Heart failure. Congestive heart failure Left ventricular failure
Conditions
Interventions
Intervention 1: intervention group: co Q10 30 mg TID
selenium 200 mcg OD. Intervention 2: control group: 2kind of Placebo as form of co q10 and selenium.
Treatment - Drugs
intervention group: co Q10 30 mg TID
selenium 200 mcg OD
control group: 2kind of Placebo as form of co q10 and selenium
Sponsors
Medical Research Department of Isfahan University
Exir Pharmaceutical Companies
Eligibility
Sex/Gender
All
Age
35 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Male and female with ischemic and nonischemic heart failure; aged between 30 to 85 years old; LVEF less than 50% (with simpson method);NYHA CLASS 2,3; stability for 1month with no change in dose and kind of drugs in at least one month perior. Exclusion criteria: ACS or Revascularization procedure in 1month before or during study;heart failure with killip class 3, 4; active Myocarditis and pricarditis; uncontroled HTN; severe renal dysfunction (GFR less than 30%); pulmonary dysfunction( PCO2 more than 45 and Po2 less than 60); liver dysfunction(CHILD 2,3).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EF (Simpson). Timepoint: before intervention- after 3 month inetrvention. Method of measurement: echocardiography.;Functional calss with NYHAN CLASS. Timepoint: BEFORE INTERVENTION-3MONTH LATER. Method of measurement: questionair. | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastrointestinal symptoms/diarrhea. Timepoint: at the end of each mounth. Method of measurement: interview.;Echocardiography parameter (LVEF Mmode, EDD, ESD). Timepoint: after and before intervention. Method of measurement: echocardiography.;Skin rash. Timepoint: each month. Method of measurement: inteview. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Parvin Bahrami
Isfahan University of Medical Sciences
Outcome results
None listed