Acute Kidney Injury. previously called acute renal failure (ARF), is a rapid loss of kidney function.
Conditions
Interventions
Intervention 1: Atorvastatin 40 mg Tab as daily during antibiotic therapy. Intervention 2: Placebo of atorvastatin as daily in all period of antibiotic therapy.
Prevention
Placebo
Atorvastatin 40 mg Tab as daily during antibiotic therapy.
Placebo of atorvastatin as daily in all period of antibiotic therapy
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients who are candidates for treatment with an aminoglycoside (gentamicin or amikacin) and at least 5 days in this study will receive antibiotics. Exclusion criteria ((Exclusion criteria: - Patients aged less than 18 or more than 65 years. - A history of kidney problems ((GFR <60ml/min - Concurrent use of other nephrotoxic drugs -Concomitant use of other drugs, antioxidants and nephroprottectivev - Patients who have contraindications to statins (hypersensitivity to the drug or drug formulation, active liver disease, unexplained and persistent increase in serum aminotransferases, pregnancy)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NGAL. Timepoint: A urine sample of the patients at baseline, 24 hours after starting treatment and at end of treatment period will be collected. Method of measurement: ELISA KIT.;Renal Toxicity. Timepoint: As daily dvaluation. Method of measurement: Based on RIFEL Criteria.;Nitric Oxide. Timepoint: A blood sample from the patients will be collected at times 0, 24h and end of treatment period. Method of measurement: ELISA Kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Renal Function status. Timepoint: End of treatment. Method of measurement: Renal Function Tests. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed