Comprasion of nifedipin versus magnesium salfate in Treatment of preterm labor

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201301281760N20

Enrollment

120

Registered

2013-05-11

Start date

2012-12-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preterm labor. Preterm labour and delivery

Interventions

Intervention 1: Intervention : Patients in Nifedipine group will receive 10mg orally and follow every 20 minutes for total four doses and assess for blood pressure.Then received 20 mg orally every 6

Treatment - Drugs

Intervention : Patients in Nifedipine group will receive 10mg orally and follow every 20 minutes for total four doses and assess for blood pressure.Then received 20 mg orally every 6 hours until 24

Control: Patients in Magnesium Sulfate group will receive 4gr bolus and follow by 2gr/h infusion. All patient assess for urinary output, DTR, respiratory rate, The drug will continue until 12 hours

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 24w-34w gestational age with a diagnosis of preterm labor; at least four contractions[During the "30 in 20 minutes with increasing cervical dilatation and effacement] (2cm dilatation or effacement of 80%). Exclusion criteria: multiple pregnancies; corioamnionitis? preeclampsia, abruption previa, liver disease, heart and blood pressure, maternal vaginal bleeding; IUGR; IUFD; Fetal distress, fetal major anomaly; PPROM; (PR> 100, BP <90/50) ³ 5cm dilatation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Premature birth control. Timepoint: Before 37 weeks of gestation. Method of measurement: Clinical.	—

Secondary

Measure	Time frame
Adverse effects of maternal magnesium sulfate versus nifedipine. Timepoint: Three days a week during the first 48 hours of onset of pain. Method of measurement: clinical.;Magnesium sulfate versus nifedipine complication rate of fetal tachycardia. Timepoint: Three days a week during the first 48 hours of onset of pain. Method of measurement: clinical.;The effect of nifedipine versus magnesium sulfate to stop the contractions of. Timepoint: Three days a week during the first 48 hours of onset of pain. Method of measurement: Clinical.	—

Measure

Time frame

Adverse effects of maternal magnesium sulfate versus nifedipine. Timepoint: Three days a week during the first 48 hours of onset of pain. Method of measurement: clinical.;Magnesium sulfate versus nifedipine complication rate of fetal tachycardia. Timepoint: Three days a week during the first 48 hours of onset of pain. Method of measurement: clinical.;The effect of nifedipine versus magnesium sulfate to stop the contractions of. Timepoint: Three days a week during the first 48 hours of onset of pain. Method of measurement: Clinical.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNargess Gholizadeh Pasha

Fatemehzahra Fertility & reproductive Health Reseach Center

ngh_pa@yahoo.com+98 11 1227 4881

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026