critically ill patients in ICU.
Conditions
Interventions
Intervention 1: Control, in this group , intramascular methadone is given to patients every 8 hour, in order to control their pain. Intervention 2: Intervention, in this group, methadone is administe
Treatment - Drugs
Control, in this group , intramascular methadone is given to patients every 8 hour, in order to control their pain
Intervention, in this group, methadone is administerd to patients via intravascular route,5mg every 8 hour, to control their pain
Sponsors
Tehran University of Medical Siences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criterion: critically ill patients in ICU, who require pain management with opioids. Exclusion criteria: hypersensitivity to methadone or any component of the formulation; patients older than 65 years old; patients with renal failure( Scr > 2mg/dl ,Urine Output <0.5cc/kg/hour) 4. ); patients with hepatic failure(hepatic enzymes more than 3 times normal); patients with Platelet less than 100000; mean arterial pressure less than 65 or who require inotrope or vasopressor and patient who suffer ALI (PaO2 /FIO2<300).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma methadone concentration. Timepoint: 1st and 6th day of the study. Method of measurement: chromatography.;Methadone plasma concentration. Timepoint: on 1st and 6th day, 1,4, 8 and 12 hours after the last dose. Method of measurement: HPLC. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr kourosh sadeghi
tehran university of medical sciences
Outcome results
None listed