Obcessive Compulsive Disorder. Obsessive Compulsive Disorder
Conditions
Interventions
Intervention 1: Tablet Topiramate 25 mg would be prescribed daily and increased 25mg weekly with respect to patient tolerance.Treatment would be continued for 3 months. Intervention 2: Tablet Placebo
Treatment - Drugs
Placebo
Tablet Topiramate 25 mg would be prescribed daily and increased 25mg weekly with respect to patient tolerance.Treatment would be continued for 3 months
Tablet Placebo 25 mg would be prescribed daily and increased 25mg weekly with respect to patient tolerance.Treatment would be continued for 3 months
Sponsors
Isfahan University Of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria:Obsessive Compulsive criteria according to DSM-IV-TR; Be used maximum tolerated dose of SSRI or Clomipramine for at least 12 weeks; moderate to severe symptoms according to Yale Brown Scale score more than 16; informed consent Exclusion criteria:primary diagnosis of psychotic or mood disorder(bipolar or MDD); subtance abuse or dependence; uncontrolled medical illness(e.g. DM,HTN,...); previous use of Topiramate; pregnancy or breastfeeding or who wants to be pregnant; convulsive disorder; suicidal thought; past history of renal stone
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Obsessive Compulsive Disorder severity. Timepoint: before intervention and after first,second and third month. Method of measurement: Yale Brown Scale and CGI scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Elham Zarean
Isfahan University Of Medical Sciences
Outcome results
None listed