Recurrent pregnancy loss. Habitual aborter
Conditions
Interventions
Intervention 1: Intra uterin infusion of G-CSF when follicle size is appropriate and 1 week after HCG. Intervention 2: Routin care
we have no intervention in control group.
Treatment - Drugs
Intra uterin infusion of G-CSF when follicle size is appropriate and 1 week after HCG
Sponsors
Reaserch center of Avicenna
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with 3 or more abortion or 2 consecutive abortion; under 40 years old; normal karyotype; normal uterus; without infectious or immunologic or endocrine or thrombotic disorders; normal thyroid function,TPO<=500; FSH<=10; LH=normal and FBS=normal. Exclusion criteria: cancer and no acceptance to participate in the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Natural Killer cells. Timepoint: 14 days after HCG. Method of measurement: Measurment of CD16-CD56. | — |
Primary
| Measure | Time frame |
|---|---|
| Abortion rate. Timepoint: 14 days after intervention- 3 months after intervention and 9 months after intervention. Method of measurement: Laboratory-ultrasonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Zafardoost Simin
Infertility and recurrent pregnancy loss center of Avicenna
Outcome results
None listed