Epilepsy. Generalized idiopathic epilepsy and epileptic syndromes
Conditions
Interventions
Intervention 1: Administration Depakin (Na valproate) IV at dose 20mg/kg stat then 1mg/kg/hour for 24 hours. Intervention 2: Administration Phenytoin (IV) at dose 18 mg/kg.
Treatment - Drugs
Administration Depakin (Na valproate) IV at dose 20mg/kg stat then 1mg/kg/hour for 24 hours
Administration Phenytoin (IV) at dose 18 mg/kg
Sponsors
Shiraz University Of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1-age>18y/o 2- SS is defined as 2 generalized tonic clonic seizures in 1 hour or more than 2 generalized tonic clonic seizures in 24 hours. Patients should regain full level of consciousness between attacks. Exclusion criteria: 1-Status epilepticus 2-Pregnancy 3-Hepatic failure 4-renal failure 5-Younger than 18 years old phenytoin such as heart disease, drug sensivity, systolic blood pressure less than 100mmhg, heart rate less than 60/min
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of seizures during 24 hours after treatment. Timepoint: 24 hours. Method of measurement: observe patient and completing a form. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac rhythm. Timepoint: continuous monitoring. Method of measurement: Heart minitoring device.;Blood pressure. Timepoint: continuous monitornig. Method of measurement: Digital blood pressure manitor.;Haert Rate. Timepoint: Continuous Monitoring. Method of measurement: Haert monitoring device. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRaeyat Mohammed Reza
Department of Neurology, Shiraz University Of Medical Sciences
Outcome results
None listed