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The effect of Intrathecal Atropine to prevent Nausea & Vomiting after surgeries due to use Intrathecal Morphine in lower limb surgeries

The effect of Intrathecal Atropine to prevent Nausea & Vomiting after surgeries due to use Intrathecal Morphine in lower limb surgeries

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013012012204N1
Enrollment
120
Registered
2013-12-09
Start date
2013-03-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Anesthesia. local anaesthetics

Interventions

Intervention 1: GroupB Spinal Anesthesia was induced using 2.5 cc of 0.5 % Hyperbaric Bupivacaine and 0.2 mg (1cc) of Intrathecal Morphine. In addition patients in group B received 1cc of saline 0.9%
Placebo
Treatment - Drugs
GroupB Spinal Anesthesia was induced using 2.5 cc of 0.5 % Hyperbaric Bupivacaine and 0.2 mg (1cc) of Intrathecal Morphine. In addition patients in group B received 1cc of saline 0.9%.
Group A Spinal Anesthesia was induced using 2.5 cc of 0.5 % Hyperbaric Bupivacaine and 0.2 mg (1cc) of Intrathecal Morphine. In addition patients in groupA received 0.1 mg (1cc) Intrathecal Atropine

Sponsors

Vice chancellor for research, Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Participants including major eligibility criteria: The patients aged from 40-70 years Participants excluding major eligibility criteria: Patients with history Neurologic disease and Neuromuscular; Diabetes Mellitus; Patients with Neuropathy Peripheral; Infection in site of injection; Sensitivity to Local Anesthesia; Patients with Vomiting and Nausea before surgery or receiving 48 hours before surgery Anti Vomiting and Nausea; Women in period of mense

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Incidence of Vomiting and Nausea. Timepoint: Incidence of Nausea and Vomiting were studied in patients within 24 hours after injection of Atropine: Hourly up to 6 hours, Then 6 hours later and Finally 12 hours later. Method of measurement: With checklist: Mild; Moderate; Severe.

Secondary

MeasureTime frame
Heart Rate. Timepoint: 3,5,10,15 Minutes after Spinal Anesthesia with receiving Atropin Interathecal. Method of measurement: Heart Rate per minute.;Blood Pressure. Timepoint: 3,5,10,15 Minutes after Spinal Anesthesia with receiving Atropin Intrathecal. Method of measurement: Blood volume pump by heart.;With out pain period. Timepoint: Intrathecal Morphine-Induced Analgesia was studied in 2 hours intervals for 12 hours after injection. Method of measurement: With checklist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Shima Hadipourzadeh

Qazvin University of Medical Sciences

fhadipourzade@qums.ac.ir+98 28 1333 6001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026