Comparison of the effect of maintenance of anesthesia with Propofol versus Isoflurane on haemorrhage during spinal surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013011911822N2

Enrollment

100

Registered

2013-02-04

Start date

2013-01-24

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

haemorrhage. During surgical operation

Interventions

Intervention 1: Infusion of propofol 100-200µ/kg/min during maintenance of anesthesia. Intervention 2: Inhalation of isoflurane 0.5-2 MAC during maintenance of anesthesia.

Treatment - Drugs

Infusion of propofol 100-200µ/kg/min during maintenance of anesthesia

Inhalation of isoflurane 0.5-2 MAC during maintenance of anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. Spine surgery for laminectomy 2. Spine surgery for fixation of fracture of vertebral column 3. 18-65 years old 4. ASA = II Exclusion criteria: 1. Refuse patient 2. Allergy to propofol 3. Allergy to soya 4. Allergy to egg 5. Allergy to isoflurane 6. History of malignant hyperthermia in patient and his or her family

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Quality of hemorrhage. Timepoint: each 20 min. Method of measurement: Boezzart criteria.;Volume of blood in suction bottle. Timepoint: At end of surgery. Method of measurement: Milliliter.;Hemoglobin. Timepoint: Preoperative and six hours postoperative. Method of measurement: g/dl.;Blood on gauzes. Timepoint: At end of surgery. Method of measurement: Weighting of gauzes (g).;Blood volume in hemovac drain. Timepoint: The day after surgery. Method of measurement: Milliliter.;Hematocrit. Timepoint: Preoperative and six hours postoperative. Method of measurement: percent.	—

Measure

Time frame

Quality of hemorrhage. Timepoint: each 20 min. Method of measurement: Boezzart criteria.;Volume of blood in suction bottle. Timepoint: At end of surgery. Method of measurement: Milliliter.;Hemoglobin. Timepoint: Preoperative and six hours postoperative. Method of measurement: g/dl.;Blood on gauzes. Timepoint: At end of surgery. Method of measurement: Weighting of gauzes (g).;Blood volume in hemovac drain. Timepoint: The day after surgery. Method of measurement: Milliliter.;Hematocrit. Timepoint: Preoperative and six hours postoperative. Method of measurement: percent.

—

Secondary

Measure	Time frame
Mean arterial blood pressure. Timepoint: each 5 min. Method of measurement: Automatic noninvasive blood pressure (mmHg).;Heart rate. Timepoint: each 5 min. Method of measurement: Electrocardiogram monitoring (per min.).;Satisfactory of surgeon. Timepoint: At end of surgery. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Karkhanei

Hamadan University of Medical sciences

karkhanei@umsha.ac.ir+98 81 1838 0574

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026