Diffuse Axonal Injury. Diffuse Brain Injury
Conditions
Interventions
Intervention 1: Cyclosporine-A, vial solution, 5mg/kg in 250 mili liter dextrose water 5% solution(DW5%) during the first 24hour of admission, one dose is administrated in all periods of the study.
Treatment - Drugs
Cyclosporine-A, vial solution, 5mg/kg in 250 mili liter dextrose water 5% solution(DW5%) during the first 24hour of admission, one dose is administrated in all periods of the study.
Intravenous, slow infusion of 250 mili liter of dextrose water 5% solution(DW5%) during the first 24hour of admission, that this solution is administrated one time in all periods of the study.
Sponsors
Vice chancellor for research, Isfahan University of Medical Science
Eligibility
Sex/Gender
All
Age
16 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria are: Age between 16 and 75 years; GCS score less than 10 in 24 hours of admission; Complete consent form; ßHCG is negative and no pregnant patients. Exclusion criteria are: Negative brain stem reflex response; Patients with immune deficiency; Liver and kidney diseases; Penetrative brain injury; Multiple trauma; Past medical history of cancer; And patients that need emergency surgery; Pregnant women
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of Consciousness. Timepoint: 1day, 3month, 6month. Method of measurement: GCS, GOS-E, MMSE. | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver Function Tests. Timepoint: 12hour, 24hour, 36hour, 48hour, 4day, 7day, 3month, 6month. Method of measurement: AST(Aspartat Aminotransferase), ALT(Alanine Aminotransferase), ALP(Alkaline Phosphatase). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Salman Abbasifard
Neurosurgery Department, Isfahan University of Medical Sciences
Outcome results
None listed