Oral lichen planus. lichen planus
Conditions
Interventions
Intervention 1: Intervention side: mucoadhesive of mycophenolate mofetil 2%,for 1month, twice daily, after breakfast at 10 & in the afternoon at 5. Intervention 2: Control side: orabase, for 1month,tw
Treatment - Drugs
Intervention side: mucoadhesive of mycophenolate mofetil 2%,for 1month, twice daily, after breakfast at 10 & in the afternoon at 5.
Control side: orabase, for 1month,twice daily, after breakfast at 10 & in the afternoon at 5.
Sponsors
Deputy of Research of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with erosive oral lichen planus with clinical manifestations and histopathological criteria; existence of two lesions with similar clinical appearance on the right and left buccal mucosa; patients older than 18 years of age. Exclusion criteria: not received any treatment for the lesions for at least 4 weeks ago; any factor that cause lichenoid reaction; any systemic or dermal disease which affects immune system of the patient; incidence of any adverse effect of mycophenolate mofetil during the study
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Size of lesion. Timepoint: Baseline and after 1 month. Method of measurement: Measured by digital culis.;Pain and burning sensation. Timepoint: Baseline and weekly for one month. Method of measurement: The oral lesions will be clinically graded based on VAS grading scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects. Timepoint: Evrey week for 1 month. Method of measurement: Clinical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNegin Samiei
Dental Faculty of Tabriz University of Medical Sciences
Outcome results
None listed