Comparison of heart rate and blood pressure changes due to administration of local anesthetic agent with and without Vasoconstrictor.

Clinical trial of comparison of heart rate and blood pressure changes due to administration of anesthesia agent with and without vasoconstrictor in healthy subjects.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013011510935N2

Enrollment

182

Registered

2013-03-09

Start date

2012-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension. Essential (primary) hypertension

Interventions

Intervention 1: Intervention group: 2% Lidocaine+ Epinephrine 1:800000, 3.6miligrams, 15 minutes before tooth extraction, Gingival injection. Intervention 2: Control group: Meoivacaine 3%, 3.6 miligra

Treatment - Drugs

Intervention group: 2% Lidocaine+ Epinephrine 1:800000, 3.6miligrams, 15 minutes before tooth extraction, Gingival injection

Control group: Meoivacaine 3%, 3.6 miligrams, 15 miutes before tooth extraction, Gingival injection

Eligibility

Sex/Gender

All

Age

25 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1-Being at the age between 25-50 years; 2-Indication for Mandibular Molar teeth extraction. Exclusion criteria: 1-History of any systematic disease; 2-History of chronic usage of any drug in the past 6 months; 3-Any allergy to Lidocaine, Mepivacaine and Adrenaline.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pulse rate. Timepoint: 15 minutes before intervention, 15 minutes after intervention. Method of measurement: Pulse rate per minute- Pulse oxymeter.;Blood Pressure. Timepoint: 15 minutes before intervention, 15 minutes after intervention. Method of measurement: Milimeter Hg- Manometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammad Ali Ghavimi

Tabriz faculty of Dentistry, Tabriz university of medical sciences

Ghavimim@Gmail.com+98 41 1335 5965

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026