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The effect of adding L-Arginine in infertile patients with refractory thin endometrium

The effect of adding L-Arginine in infertile patients with refractory thin endometrium: A randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130115012146N10
Enrollment
84
Registered
2024-09-12
Start date
2024-10-11
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention Group: In patients with a thin endometrium, L-arginine (manufactured by Karan Pharmaceuticals and Vital Nutritional Supplements) of one gram is administered every 12 hours
otherwise, they are discontinued. Intervention 2: Control group: In this group, Estradiol valerate 2 mg is given every 8 hours for 3 days and then every 6 hours for another 3 days along with L-Arginin

Sponsors

Vice chancellor for Research, Tabriz University Of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 42 Years

Inclusion criteria

Inclusion criteria: Age between 20-42 years. Infertile women are candidates for fertility treatments. Endometrial thickness less than 7 millimeters. Treatment-resistant endometrium Consent to participate in the study

Exclusion criteria

Exclusion criteria: Submucosal fibroids Endometrial polyp Severe endometriosis Adenomyosis and uterine abnormality Having an allergic reaction to L-arginine

Design outcomes

Primary

MeasureTime frame
Chemical pregnancy rate. Timepoint: 2 weeks after embryo transfer. Method of measurement: HCG blood test.;Implantation rates. Timepoint: 3-5 weeks after the transfer. Method of measurement: Ultrasound.

Secondary

MeasureTime frame
Clinical pregnancy. Timepoint: 5-4 weeks after embryo transfer. Method of measurement: Viewing the fetal heartbeat in transvaginal ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Farzadi Laaya

Tabriz University of Medical Sciences

lahroudin@gmail.com+98 41 3553 9160

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026