Respiratory failure of newborns. Respiratory failure of newborns
Conditions
Interventions
Intervention 1: Nasal intermittent positive pressure ventilation (NIPPV) involves giving continuous positive airway pressure (CPAP) to the infant in the intermittent mandatory ventilation (IMV) mode.
Treatment - Devices
Nasal intermittent positive pressure ventilation (NIPPV) involves giving continuous positive airway pressure (CPAP) to the infant in the intermittent mandatory ventilation (IMV) mode.
Conventional mechanical ventilation is a methode of ventilation that paitient have endotheracheal intubation and and connect to ventilator by that.
Sponsors
Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: getational age less than 35 weeks; birth weight less than 2500 grams; CPAP failure (Fio2 more than 60% and maximum CPAP 8 cmH2O and/or PH less than 7.2 and PCO2 more than 60 and/or more than 3 episodes apnea with bradicardia (heart rate less than 80 per minute in 20,31,35 hours). exclusion criteria: nasopharyngeal pathology; coanal atresia; cleft/lip palate; major anomalies especially thorasic or cardiac anomalies; intra ventricular hemorrhage (IVH) grade 3 or 4 on admission; their parents refuse to participate in the research project.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment. Timepoint: during hospitalization and using NIPPV and conventional mechanical ventilation. Method of measurement: comparing survival rates according to serial arterial blood gass (ABG) sampling. | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of bronchopulmonary dysplasia (BPD). Timepoint: during hospitalization and using NIPPV and conventional mechanical ventilation. Method of measurement: Taking CXR on addmission and weaning.;Incidence of intra ventricular hemorrhage (IVH). Timepoint: during hospitalization and using NIPPV and conventional mechanical ventilation. Method of measurement: cranial ultrasonography on addmission and deterioration of clinical statys.;Incidence of patient dactus arteriosus (PDA). Timepoint: during hospitalization and using NIPPV and conventional mechanical ventilation. Method of measurement: Echocardiography on addmission and deterioration of clinical status.;Incidence of necrotizing enterocolitis (NEC). Timepoint: during hospitalization and using NIPPV and conventional mechanical ventilation. Method of measurement: According to Bell's criteria.;Incidence of pneumothorax. Timepoint: during hospitalization and using NIPPV and conventional mechanical ventilation. Method of measurement: Taking CXR on addmission and deterioration on clinical status. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBabak Nekooie
Isfahan University of Medical Sciences
Outcome results
None listed