Effect of premedication with Indomethacin and Ibuprofen on postoperative Endodontic pain

Effect of Indomethacin and Ibuprofen on postoperative Endodontic pain in referring patients to the Endodontic department with dental pain

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013010712048N1

Enrollment

Registered

2016-01-05

Start date

2011-07-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of premedication with Indomethacin and Ibuprofen on postoperative endodontic pain.

Interventions

Ibuprofen/400mg/capsule/1 hours befor treatment

Placebo/capsule/1 hours before treatment

Intervention 1: Indomethacin/25mg/capsule/1 hours befor treatment. Intervention 2: Ibuprofen/400mg/capsule/1 hours befor treatment. Intervention 3: Placebo/capsule/1 hours before treatment.

Treatment - Drugs

Treatment - Other

Placebo

Indomethacin/25mg/capsule/1 hours befor treatment

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with first and second molars with irreversible pulpitis having normal radiographic view without any lesion or fistula? exhibit a long response to the pulp tester and cold testing exclusion criteria: individual younger than 18 years and older than 50 years? Consumption of analgesic drug 12 hours before treatment? Allergic history to NSATDs or Lidocaine with 1/80000 Epinephrine? patients with systemic disease? Take contraindicated drugs with NSAIDs?Pregnancy and nursing? teeth with periapical lesion or acute periapical abscess? aggressive periodontal disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The analgesic effect. Timepoint: 8,12,24 hours after treatment. Method of measurement: By Visual Analogus Scale(VAS).	—

Secondary

Measure	Time frame
Gastritis. Timepoint: After treatment. Method of measurement: Grade (low, intermediate, high).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZeinab Hamzeheil

Shahid Sadoughi University of Medical Science

n_hamzeiil@yahoo.com; z.hamzeheil@ssu.ac+98 35 1625 6975

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026