Evaluation of intravenous acetaminophen & Diclophenac Suppository on postoperative pain reduction in cesarean section.

Comparative effect of intravenous acetaminophen and suppository of diclophenac on pain relief after elective cesarean section under spinal anesthesia.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013010710841N3

Enrollment

Registered

2013-04-12

Start date

2013-02-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cesarean postoperative pain. Complication of anaesthesia during the puerperium, unspecified

Interventions

Intervention 1: After skin closure in Acetaminophen group 1gr IV acetaminophen in 100ml N/S within 30 minutes association to placebo suppository is adminstrated and the same in obstetric ward by nur

Treatment - Drugs

After skin closure in Acetaminophen group 1gr IV acetaminophen in 100ml N/S within 30 minutes association to placebo suppository is adminstrated and the same in obstetric ward by nursing in QID.

After skin closure in Diclophenac group 100ml IV N/S within 30 minutes association to Diclophenac suppository is adminstrated and the same in obstetric ward by nursing in QID.

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:Parturients with ASA class 1&2; 18-45 years;candidate for elective cesarean section under spinal anesthesia. Exclusion criteria:Liver disease;Renal disease;Cardiac disease;Hypertension;Peptic ulcer;Pre-eclampsia&Eclamsia;Diabetes;Allergic reaction;Emergency cesarean section;Bleeding disorder or Anticuagolant drug History;Increasing ICP;Local skin infection;Neurologic disorders.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: 10 centimeter ruller.;Systolic Blood Pressure. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Diastolic Blood Pressure. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Heart rate. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: Pulse oximetry.;Blood oxygenation. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: Pulse oximetry.;Analgesic requirement in 24 hours. Timepoint: During 24 hours. Method of measurement: Questionnaire.;Patients satisfaction. Timepoint: During 24 hours. Method of measurement: Questionnaire.	—

Measure

Time frame

Pain score. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: 10 centimeter ruller.;Systolic Blood Pressure. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Diastolic Blood Pressure. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Heart rate. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: Pulse oximetry.;Blood oxygenation. Timepoint: Before drug adminstration; arrive to recovery; 15 minutes after stay in recovery; exit from recovery; 2, 4, 6,1 2, 18 & 24 hours after sergury. Method of measurement: Pulse oximetry.;Analgesic requirement in 24 hours. Timepoint: During 24 hours. Method of measurement: Questionnaire.;Patients satisfaction. Timepoint: During 24 hours. Method of measurement: Questionnaire.

—

Secondary

Measure	Time frame
Nausea. Timepoint: during 24 hours. Method of measurement: Observation.;Vomiting. Timepoint: during 24 hours. Method of measurement: Observation.;Epigastric Pain. Timepoint: During 24 hours. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Manouchehrian

Hamadan University of Medical Science

nmanuchehrian@yahoo.commanouchehrian@umsha.ac.ir+98 81 1827 7012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026