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Comparison of the effect of Diazepam and Etomidate on cardiovascular system after laryngoscopy and intubation

Comparison of the effect of Diazepam and Etomidate on hemodynamic responses to laryngoscopy and intubation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013010512007N1
Enrollment
180
Registered
2013-01-26
Start date
2012-09-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intubation. Failed or difficult intubation

Interventions

Treatment - Drugs
Intervention 1: Intervention: Diazepam (each ampoule contains10mg/2ml , made by Kimidaroo/Iran) injecting IV with dosage of 0.4mg/kg before induction of anesthesia. Intervention 2: Control group: Etom
Intervention: Diazepam (each ampoule contains10mg/2ml , made by Kimidaroo/Iran) injecting IV with dosage of 0.4mg/kg before induction of anesthesia
Control group: Etomidate (each ampoule contains20mg/10ml , made by Janssen-Cling/Australia) injecting IV and stat with dosage of 0.3mg/kg before induction of anesthesia

Sponsors

Deputy of Research Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria are: American Association of Anesthesiologists’ (ASA) classification of I or II; age 25 -65 years. Exclusion criteria are: ASA classification of 3-6 (severe systemic disorders such as CRF and CHF); patients with fever, anemia, seasonal or food allergy or known medicine hypersensitivity; hypertension;, hypo tension; consumption of beta blockers; kidney and liver disorders; drug abuse; dehydration and anxious patients with heart rate of100 b/m or more.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: after lying on surgical bed, immediately after intubation, 5 and 10 minutes later. Method of measurement: digital monitoring device.;Heart rate. Timepoint: after lying on surgical bed, immediately after intubation, 5 and 10 minutes later. Method of measurement: digital monitoring device.

Secondary

MeasureTime frame
Awareness. Timepoint: at the end of anesthesia. Method of measurement: asking the patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Khodadadzadeh

Kerman University of Medical Sciences

javadkordi@yahoo.com+98 34 1223 5011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026