oral lichen planus. lichen planus
Conditions
Interventions
propolis capsule 500 mg daily for one month.
Treatment - Drugs
propolis capsule 500 mg daily for one month
Sponsors
Deputy of Research of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with ulcerative oral lichen planus with clinical manifestations and histopathological criteria including: 1-Areas of hyper parkeratosis or hyper orthokeratosis, often with thickening of granular cell layer and saw-toothd appearance to the retepegs. 2-liquefaction degeneration or necrosis of basal cell layer. 3-sub epithelial band like infiltration of T lymphocyte and macrophage. Exclusion criteria: any factor that cause lichenoid reaction like as drug use or presence of amalgam restoration adjucent to lesions; any disease that suppresses immune system,such as HIV or Iv drug abuse,and any disease in which doing biopsy has medical complications; use of drug during one month ago for treatment of olp or use of antibiotic or corticosteroid or any drug that can suppress lymphocyte activity(for confidence that drugs don't change serum level of il-17); report of dysplasia or malignancy in patients pathology; history of dermal or digestive hypersensitivity to propolis; unwillingness to participate in study at any stages and report of side effects from patients or researchers.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of il-17. Timepoint: At the begining of research-one month later. Method of measurement: Elisa kit (ebio science company). | — |
Secondary
| Measure | Time frame |
|---|---|
| Size of lesions. Timepoint: At the beigining of the research-one month later. Method of measurement: Mesurment of lesion size at the begining of research with digital colis and then mark the changes by researcher in future follwing.;Pain and burning sensation. Timepoint: At the beigining of the research-one month later. Method of measurement: VAS scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Reza Tavakoli Ataabadi
Dental Faculty of Tabriz University of Medical Sciences
Outcome results
None listed