Comparison of the effect of two drugs Alloprinol and Aminophylline in the treatment of neonates with asphyxia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20121229011923N7

Enrollment

Registered

2019-12-23

Start date

2020-02-20

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asphyxia. Asphyxia

Interventions

Intervention 1: Intervention group: In the first hour, the first intervention group received 5mg / kg intravenous aminophylline as STAT and two hours after neonatal admission to the neonatal intensive

Eligibility

Sex/Gender

All

Age

1 Days to 1 Days

Inclusion criteria

Inclusion criteria: 5 minute apgar less than 5 The pH of the cord artery is less than

Exclusion criteria

Exclusion criteria: Parental dissatisfaction Premature infants with congenital and chromosomal abnormalities and renal and abdominal malformations Mother with gestational diabetes

Design outcomes

Primary

Measure	Time frame
Improve kidney function. Timepoint: To evaluate the performance of all BUN, Cr and electrolyte measurements (Na and k) one day in between for one week. Method of measurement: Blood test.;Improve brain function. Timepoint: Daily. Method of measurement: The nervous system is also monitored daily by Moro, sucking, Grasping reflexes and the DTR index (deep tendon reflex). And if they are normal, we move one shot at a time, and we have the same direction with the muscle that we hit. Depending on the reflex we can score 4 (score 0): Under no circumstances can reflex be achieved, (+1 score): We can get reflex when the patient is distracted and reflex is reduced (+2 score) : The reflex is normal, (+3 score) when we have expansion at the point of insertion (reflex can also be achieved at other locations), (+4 score): when clonus This means that when a blow is made, the reflex is repeated several times, and the movement is repeated several times, with a score of 0 or 4 and 3 meaning a brain injury.	—

Measure

Time frame

Improve kidney function. Timepoint: To evaluate the performance of all BUN, Cr and electrolyte measurements (Na and k) one day in between for one week. Method of measurement: Blood test.;Improve brain function. Timepoint: Daily. Method of measurement: The nervous system is also monitored daily by Moro, sucking, Grasping reflexes and the DTR index (deep tendon reflex). And if they are normal, we move one shot at a time, and we have the same direction with the muscle that we hit. Depending on the reflex we can score 4 (score 0): Under no circumstances can reflex be achieved, (+1 score): We can get reflex when the patient is distracted and reflex is reduced (+2 score) : The reflex is normal, (+3 score) when we have expansion at the point of insertion (reflex can also be achieved at other locations), (+4 score): when clonus This means that when a blow is made, the reflex is repeated several times, and the movement is repeated several times, with a score of 0 or 4 and 3 meaning a brain injury.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAkram Hemmatipour

Faculty of Medical Sciences Shoushtar

hematipour.a64@gmail.com+98 61 3622 2221

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026