Subacute Traumatic Spinal cord injury

Efficacy and Safety of intraspinal injection of Neural stem cell on progression of subacute Traumatic spinal cord injury

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012122611889N1

Enrollment

Registered

2013-03-11

Start date

2013-02-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic spinal cord injury. Other of spine injury trunk other specified

Interventions

Injection of neural stem cell intraspinal cord upper and lower part of lesion T1-T10

From bilateral posterior iliac crest bone marrow in the operating room during a procedure by an Oncologist and Neurosurgeon is taken entirely standard. Stem cells in the laboratory by a team of specia

Treatment - Other

Eligibility

Sex/Gender

All

Age

15 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria : Definite paraplegic classification supported Franklin (A); Disease progression between 2-3 weeks; SCI region (T1-T10); Age range 15-55 years Exclusion Criteria: History of cortical brain damage; GCS<10 (Coma); MS; Any major systemic or psychiatric illness; History of hypertension; Diabetes; Any major pathology in brain or spinal cord; Pregnancy; Any major systematic or psychiatric illness before trauma; Any coexisting neurodegenerative disease; History of stem cell; history of Hematologic or lymphoproliferative transplantation; History of spinal cord injury or spinal surgery; History of Hepatitis and HIV

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Quality of life. Timepoint: Before and 6 months after intervention. Method of measurement: Asia (american spinal injury association) Score, SCIM(spinal cord independent measure) questionnaire.;Disability. Timepoint: Before and 6 months after intervention. Method of measurement: Asia(American Spinal Injury Association) Score, SCIM(Spinal Cord Independent Measure) questionnaire.;Electrophysiologic parameters (EMG,NCV- SSEP,MMEP). Timepoint: Before and 6 months after intervention. Method of measurement: EMG, NCV, Evoked.;Urinary and fecal incontinency. Timepoint: Six months. Method of measurement: UDS(Urodynamic Study).	—

Measure

Time frame

Quality of life. Timepoint: Before and 6 months after intervention. Method of measurement: Asia (american spinal injury association) Score, SCIM(spinal cord independent measure) questionnaire.;Disability. Timepoint: Before and 6 months after intervention. Method of measurement: Asia(American Spinal Injury Association) Score, SCIM(Spinal Cord Independent Measure) questionnaire.;Electrophysiologic parameters (EMG,NCV- SSEP,MMEP). Timepoint: Before and 6 months after intervention. Method of measurement: EMG, NCV, Evoked.;Urinary and fecal incontinency. Timepoint: Six months. Method of measurement: UDS(Urodynamic Study).

—

Secondary

Measure	Time frame
Forced vital capacity. Timepoint: six months. Method of measurement: Spirometry (PFT).;Muscle Strength. Timepoint: six months after intervention. Method of measurement: MRC, Questionnaire.;Side effects (Transplantation site hematoma and edema spinal cord- Anaphylaxis shock ). Timepoint: After intervention and 6 months after intervention. Method of measurement: Questionnaire,Examination, MRI.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactTaheri Taher

Shefa Neuroscience Research Center, Khatamolanbia Hospital

TaherTaheri@khatamhospital.com; SCI@Neuroscience.ir+98 21 8355 3530

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026