Effect of pentoxifyllin in diabetic foot

Effect of pentoxifyllin and its compration with placebo as an adjunctive drug in diabetic foot ulcer in diabetic patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012122411872N1

Enrollment

Registered

2013-02-24

Start date

2013-01-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Diabetes. Condition 2: Diabetes. Condition 3: diabetes. Condition 4: diabetes. Condition 5: diabetes. Insulin-dependent diabetes mellitus Unspecified diabetes mellitus Malnutrition-related diabetes mellitus Other specified diabetes mellitus non-Insulin-dependent diabetes mellitus

Interventions

Intervention 1: for intervention group

tab Pentoxifylline 400mg every eight hours for 6 Month. Intervention 2: for control group

placebo every eight hours for six month.

Treatment - Drugs

for intervention group

tab Pentoxifylline 400mg every eight hours for 6 Month.

for control group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: inclusion critria:Diabetic patients with diabetic foot ulcer grade 2 and 3 wagner exclusion critria:dyspepsia; sensitivity to pentoxifylline; Sensitivity to methylxanthines;limb vascular occlusion more than 80 percent.

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

Measure	Time frame
Ankle/brachial index improvement. Timepoint: weekly in first month then every month up to six months. Method of measurement: with sphingomanometery and with mmHg unit.;Amputation need. Timepoint: weekly in first month then every month up to six months. Method of measurement: with physical exam , need or dont need.;Debridmeant need. Timepoint: weekly in first month then every month up to six months. Method of measurement: with physical exam, need or dont need.	—

Measure

Time frame

Ankle/brachial index improvement. Timepoint: weekly in first month then every month up to six months. Method of measurement: with sphingomanometery and with mmHg unit.;Amputation need. Timepoint: weekly in first month then every month up to six months. Method of measurement: with physical exam , need or dont need.;Debridmeant need. Timepoint: weekly in first month then every month up to six months. Method of measurement: with physical exam, need or dont need.

—

Primary

Measure	Time frame
Healing of diabetic foot ulcers. Timepoint: weekly in first month then every month up to six months. Method of measurement: CM and MM.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBarabadi Hassan

Jundishapur University of Medical Sciences

hassan.barabadi@gmail.com+98 61 1374 3001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026