Mild subclinical hypothyroidism. Subclinical iodine-deficiency hypothyroidism
Conditions
Interventions
Intervention 1: Intervention group: synbiotic capsule which contains bacterial species Lactobacillus rhamnoses, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus helveticus, Lactobacillus a
Sponsors
Research vice- chancellor of Tabriz university of medical sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Newly diagnosed patients with mild subclinical hypothyroidism TSH level between 4 and 10 IU/ml Willingness to cooperate in the project 20-65 years Suffering from mild subclinical hypothyroidism
Exclusion criteria
Exclusion criteria: Hormone therapy and the use of hormonal drugs The contraceptive drugs usage The anti-inflammatory drugs usage The blood lipid-lowering drugs consumption The probiotic supplements consumption in the last 3 months before the study and during the study The antibiotic drugs usage during the study S?ynbiotic supplement intolerance during the study Immune system disorders Immunosuppressive drugs or chemotherapy consumption Cardiovascular diseases, active ulcerative colitis, short bowel syndrome, acute and chronic infectious diseases History of drug or food allergies Pregnancy and breastfeeding Smoking Alcohol consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiome metabolite (LPS). Timepoint: Before the intervention and two months after the intervention. Method of measurement: By laboratory ELISA kits. | — |
Secondary
| Measure | Time frame |
|---|---|
| Total cholesterol (TC). Timepoint: Before the intervention and two months after the intervention. Method of measurement: By laboratory ELISA kits.;Triglyceride (TG). Timepoint: Before the intervention and two months after the intervention. Method of measurement: By laboratory ELISA kits.;Apo A1. Timepoint: Before the intervention and two months after the intervention. Method of measurement: By laboratory ELISA kits.;Apo B. Timepoint: Before the intervention and two months after the intervention. Method of measurement: By laboratory ELISA kits. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNaimeh Mesri Alamdari
Tabriz University of Medical Sciences
Outcome results
None listed