lichen planus. lichen planus tropicus
Conditions
Interventions
Intervention 1: control:The standard treatment of oral prednisolone 0.5 mg per kg daily until complete recovery or up to 8 weeks. Intervention 2: intervention: enoxaparin 5 mg subcutaneously weekly un
Treatment - Drugs
control:The standard treatment of oral prednisolone 0.5 mg per kg daily until complete recovery or up to 8 weeks
intervention: enoxaparin 5 mg subcutaneously weekly until complete remission or a maximum of 8 weeks
Sponsors
Vice chancellor for Administrative and Financial of Medical School
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with disseminated lichen planus at least 6 months represent to the clinic. Exclusion criteria: 1. Contraindications of heparin and its derivatives, including: hemostasis, acquired or congenital disorder, the risk of bleeding caused by uncontrolled hypertension, active peptic ulcer, recent cerebrovascular accident, sensitivity to enoxaparin or heparin derivatives; 2. Chronic liver disease; 3. Hepatitis B and C; 4. Contraindications for taking oral prednisone; 5. Medications that are known to lead to the LP like reaction; 6. Lichen planus of nails; 7. Scalp involvement; 8. Ulcerated mucosal lesions; 9. Heparin therapy complications such as drug sensitivity, acute bleeding.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pruritus. Timepoint: befor treatment-weekly in treatment period- in 1,3 and 6 months following end of treatment. Method of measurement: visual analogue scale(VAS).;Extention of active lesions. Timepoint: befor treatment-weekly in treatment period- in 1,3 and 6 months following end of treatment. Method of measurement: percentage of skin surface. | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding. Timepoint: weekly in period of treatment. Method of measurement: Observation (yes or no).;Hypersensitivity. Timepoint: weekly in period of treatment. Method of measurement: Observation (yes or no). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAhmad Saeidi
Isfahan University of Medical Sciences
Outcome results
None listed