Evaluation of drug injection rate on hypotension incidence during spinal anesthesia

The effect of intrathecal injection rate of bupivacaine 0.5% on maternal sensory level and hypotension during elective cesarean delivery under spinal anesthesia.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012122210841N2

Enrollment

Registered

2013-02-03

Start date

2012-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bupivacaine injection rate in spinal anesthesia. Other complications of spinal and epidural anaesthesia during pregnancy

Interventions

Intervention 1: Moderate group patients recieved 750 ml serum Ringer and anesthetized with spinal anesthesia in sitting position . 10 mg bupivacaine %0.5(2/5 ml)combined 0/5ml sufentanil(total vol

Prevention

Moderate group patients recieved 750 ml serum Ringer and anesthetized with spinal anesthesia in sitting position . 10 mg bupivacaine %0.5(2/5 ml)combined 0/5ml sufentanil(total volume=3ml) by 25 G

Fast group patients recieved 750 ml serum Ringer and anesthetized with spinal anesthesia in sitting position . 10 mg bupivacaine %0.5(2/5 ml)combined 0/5ml sufentanil(total volume=3ml) by 25 Gneed

Slow group patients recieved 750 ml serum Ringer and anesthetized with spinal anesthesia in sitting position . 10 mg bupivacaine %0.5(2/5 ml)combined 0/5ml sufentanil(total volume=3ml) by 25 Gneed

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with ASA class 1&2; 18-40 years old; term pregnancy >37 week ; patients sheduled for elective cesarean section under spinal anesthesia. Exclusion criteria: Twin pregnancy ; emergency cesarean section ; pre-eclampsia; ecclampsia & maternal hypertension; cardiac disease; contraindications for spinal anesthesia (patients refusal, increase of ICP, skin infection, cuagulation disease, hypovolemia, previous neural problems and inexpert anesthesiologist)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systolic Blood Pressure. Timepoint: Systolic blood pressure was measured every 1 minute up to 15 minutes after spinal anesthesia.and every5 minutes up to 30 minutes and every 10 minutes up to end of surgery(60 minutes). Method of measurement: using non invasive blood pressure monitoring.;Diastolic Blood Pressure. Timepoint: Diastolic blood pressure was measured every 1 minute up to 15 minutes after spinal anesthesia.and every5 minutes up to 30 minutes and every 10 minutes up to end of surgery(60 minutes). Method of measurement: Non invasive Blood Pressure Monitoring.;Heart rate. Timepoint: Heart rate was measured every 1 minute up to 15 minutes after spinal anesthesia.and every5 minutes up to 30 minutes and every 10 minutes up to end of surgery(60 minutes). Method of measurement: Pulse oximetry.;Sensory level. Timepoint: after spinal anesthesia and befor surgery. Method of measurement: With needle in anterior axillary line and bilateral.;Motor level. Timepoint: After spinal anesthesia and befor surgery. Method of measurement: Observation & Examination and Bromage score(0 = no motor block, 1 = inability to raise the extended leg, 2 = inability to flex the knee, 3 = inability to flex the ankle).	—

Measure

Time frame

Systolic Blood Pressure. Timepoint: Systolic blood pressure was measured every 1 minute up to 15 minutes after spinal anesthesia.and every5 minutes up to 30 minutes and every 10 minutes up to end of surgery(60 minutes). Method of measurement: using non invasive blood pressure monitoring.;Diastolic Blood Pressure. Timepoint: Diastolic blood pressure was measured every 1 minute up to 15 minutes after spinal anesthesia.and every5 minutes up to 30 minutes and every 10 minutes up to end of surgery(60 minutes). Method of measurement: Non invasive Blood Pressure Monitoring.;Heart rate. Timepoint: Heart rate was measured every 1 minute up to 15 minutes after spinal anesthesia.and every5 minutes up to 30 minutes and every 10 minutes up to end of surgery(60 minutes). Method of measurement: Pulse oximetry.;Sensory level. Timepoint: after spinal anesthesia and befor surgery. Method of measurement: With needle in anterior axillary line and bilateral.;Motor level. Timepoint: After spinal anesthesia and befor surgery. Method of measurement: Observation & Examination and Bromage score(0 = no motor block, 1 = inability to raise the extended leg, 2 = inability to flex the knee, 3 = inability to flex the ankle).

—

Secondary

Measure	Time frame
Nausea. Timepoint: During surgery. Method of measurement: Observation.;Vomiting. Timepoint: during surgery. Method of measurement: Observation.;Efedrine Dosage. Timepoint: Ending of surgery. Method of measurement: Measurement of efedrine.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Manouchehrian

Hamadan University of Medical Sciences

manouchehrian@umsha.ac.ir ; nmanuchehrian@yahoo.com+98 81 1821 0173

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026