Ankylosing spondylitis. Ankylosing spondylitis
Conditions
Interventions
Intervention 1: Control group will receive placebo for 12 months. Intervention 2: Treatment group will receive alendronate sodium 70 mg tablet (Ostomod, Modava company) with 70mg/week (one tablet at w
Treatment - Drugs
Control group will receive placebo for 12 months.
Treatment group will receive alendronate sodium 70 mg tablet (Ostomod, Modava company) with 70mg/week (one tablet at week)dose orally for 12 months. Alendronate is a bisphosphonate which binds to the
Sponsors
Vice chancellor for research, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Schober index=5; Normal hip joint in the pelvic radiography; Absence or rarity of syndesmophyte in the spine radiography (Taylor index=1); Normal bone density or mild osteopenia (T-score=-1.5) Exclusion criteria: Use of drugs which increase bone density like bisphosphonates; Use of steroids and biological agents; Coexistence of other disease which decreases bone density: including hyperparathyroidism, diabetes, hyper and hypothyroidism, osteomalasia, liver failure, renal failure
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone density. Timepoint: 12 months after intervention (at the end of study). Method of measurement: Bone mineral density measurement as gram/cm² by the DEXA method with Hologic QRD model instrument from lumbar and pelvic area. | — |
Secondary
| Measure | Time frame |
|---|---|
| Osteoporotic fracture. Timepoint: Every 3 months until 12 months. Method of measurement: History, physical examination, and radiography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehrzad Hajiallilo
Tabriz University of Medical Sciences
Outcome results
None listed