Condition 1: Diabetis. Condition 2: Transplanted kidney. Insulin-dependent diabetes mellitus transplanted kidney
Conditions
Interventions
Intervention 1: intervention group:
30 mg Pioglitazone once daily for 4 month. Intervention 2: control group:
placebo tablet once daily for 4 month.
Treatment - Drugs
intervention group:
30 mg Pioglitazone once daily for 4 month
control group:
placebo tablet once daily for 4 month
Sponsors
Deputy of Research and Technology, Shahid beheshti pharmacy faculty
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1-diabetis mellitus. 2- stable renal function at the initiation of study or 1 month after transplantation. 3- using insulin before study Exclusion criteria: 1- acute febrile episodes. 2- GFR less than 30 ml/dl before the study. 3-hepatitis B , C. 4- CHF (New York Heart Association II-IV) 5-pregnancy. 6-receiving pulse corticostroids. 7-Acute rejection at 2 week before of study starting.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Malondialdehyd plasma level. Timepoint: at the begining and end. Method of measurement: Pg/mL.;Total protein carbonyls plasma level. Timepoint: at the begining and end. Method of measurement: Pg/mL kit.;IL-18 plasma level. Timepoint: at the begining and end. Method of measurement: (Pg/mL) kit.;Fast blood glucose. Timepoint: monthly. Method of measurement: kit ( mg/dL).;ESR level. Timepoint: monthly. Method of measurement: (Pg/mL) kit.;CRP plasma level. Timepoint: monthly. Method of measurement: (ng/mL) kit.;HbA1C level. Timepoint: monthly. Method of measurement: (mIU/mL) kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Kharazmkia
Shahid Beheshti University of Medical Sciences
Outcome results
None listed