Infertility and treatment methods. Female infertility associated with anovulation
Conditions
Interventions
Intervention 1: Group A patients received 5 mg/day letrozole at days 5-9 menstrual cycle before IUI (n=72). All patients received 150 IU rFSH (Gonal-f, Serono, Hellas, Puregon, Greece) from day 8 unti
Treatment - Drugs
Group A patients received 5 mg/day letrozole at days 5-9 menstrual cycle before IUI (n=72). All patients received 150 IU rFSH (Gonal-f, Serono, Hellas, Puregon, Greece) from day 8 until day of hCG adm
Group B received 100-mg per day clomiphene citrate (Razak Drug Laboratory, Tehran, Iran) for 5 days in at days 5-9 menstrual cycle and 150 IU rFSH from day 8 until day of hCG administration.10000 IU o
Sponsors
Shiraz university of medical sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: We included those 18–40 years old patients who suffered from unexplained infertility, mild male factor (according to World Health Organization criteria), PCOS, cervical factors and mild endometriosis. Exclusion criteria: Cigarette smoking and alcohol abuser (both partner), ovarian hyperstimulation syndrome
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy. Timepoint: two weeks after the missed period. Method of measurement: measuring level of blood BhCG by ELISA.;Endometrial thickness. Timepoint: when human chorionic gonadotropin (hCG) was injected. Method of measurement: measure by transvaginal sonoghraphy at its greatest diameter perpendicular to the midsagittal plane at the fundal region of the uterus. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate. Timepoint: 4weeks after the missed period. Method of measurement: detecting of intrauterine sac by vaginal sonography.;Multiple pregnancy. Timepoint: 4 weeks after the missed period. Method of measurement: detecting of intrauterine sacs by vaginal sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Afsun Zarei
Shiraz university of medical sciences
Outcome results
None listed